China Oncology ›› 2015, Vol. 25 ›› Issue (5): 377-381.doi: 10.3969/j.issn.1007-3969.2015.05.010

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The expressions of IL-2, IL-6 and TNF-α in the serum of extranodal NK/T-cell lymphoma (ENKTL) patients and their clinical significances

WANG Yuanyuan, LI Zhaoming, ZHANG Xudong, ZHANG Mingzhi   

  1. Lymphoma Diagnosis and Treatment Center, First Affiliated Hospital, Zhengzhou University, Zhengzhou Henan 450052, China
  • Online:2015-05-30 Published:2015-08-11
  • Contact: ZHANG Mingzhi E-mail: mingzhi_zhang1@163.com

Abstract:     Background and purpose: Extranodal NK/T-cell lymphoma, nasal type (ENKTL) belongs to a rare type of non-Hodgkin's lymphoma (NHL). Its incidence rate in Asian country is higher than that in Western country. This disease is highly invasive, the pathogenesis of it is still unclear. Resent research shows that epstein-barr virus (EBV) is closely related to the occurrence of it. There is still no standard treatment guidelines of ENKTL, and the prognosis is very bad. Therefore, it is imperative to explore the pathogenesis of ENKTL. This study aimed to investigate the expressions of interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the serum of ENKTL patients and their clinical significances. Methods: Luminex liquid chip technology was used to detect the expression levels of IL-2, IL-6 and TNF-α in the serum of 67 ENKTL patients and 26 normal persons. Results: The expression levels of IL-2, IL-6 and TNF-α in the serum of 67 ENKTL patients were (564.1±387.6), (293.3±191.6) and (181.3±91.8)pg/mL, while in the normal persons were (1 097.0±365.7), (417.5±289.6) and (291.3±89.4)pg/mL, respectively. Compared with normal persons, the expression levels of IL-2, IL-6 and TNF-α in ENKTL patients were significantly lower (P<0.05). Further study showed that the expression level of TNF-α in 5 complete remission ENKTL patients [(162.7±10.3)pg/mL] was significantly higher than that in initial treatment patients [(125.2±7.3)pg/mL, P<0.05]. Conclusion: The expressions of IL-2, IL-6 and TNF-α are reduced in the serum of ENKTL patients, and the serum expression level of TNF-α is closely related to the effect of chemotherapy.

Key words: Extranodal NK/T-cell lymphoma, nasal type, Interleukin-2, Interleukin-6, Tumor necrosis factor-α, Inflammation