乳腺癌中心体调控蛋白SEC23B在肿瘤浸润转移中的作用及其机制研究

冷婕, 邱国春, 张菠, 蒲艳

Mechanism of breast cancer centrosome regulatory protein SEC23B on tumor invasion and metastasis

LENG Jie, QIU Guochun, ZHANG Bo, PU Yan

图5 SEC23B敲低在体内抑制乳腺癌转移和自噬

Fig. 5 SEC23B knockdown inhibits breast cancer metastasis and autophagy in vivo A: Tumors were excised 21 days after implantation and final tumor weight was recorded. B: Histological examination by H-E staining was performed to determine tumor morphology and structural changes. Tumor necrosis was indicated by a red arrow. C: Lung metastases were examined by H-E staining. Tumor metastases in lung tissue were indicated by yellow arrows. D: Lung tissue was excised and fixed in Bouin solution 21 days after implantation, and the number of metastatic nodules was recorded for each mouse. Metastatic nodules were indicated by black arrows. E: LC3 expression in tumor tissues was examined by H-E staining. **: P<0.01, compared with sh-NC group; ***: P<0.001, compared with sh-NC group.