Recent advances in breast cancer stem cell phenotypes and clinical application

赵　宁; 傅　深

doi:10.19401/j.cnki.1007-3639.2016.08.010

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Recent advances in breast cancer stem cell phenotypes and clinical application

更新时间：2025-12-31

- Recent advances in breast cancer stem cell phenotypes and clinical application
- China Oncology Vol. 26, Issue 8, Pages: 699-703(2016)
- 作者机构：
  
  1. 上海交通大学附属第六人民医院肿瘤放疗科,上海,200233
  2. 复旦大学附属肿瘤医院放射治疗中心，上海市质子重离子医院放射治疗科，复旦大学上海医学院肿瘤学系,上海,201321
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2016.08.010
  CLC：
- Published Online：19 October 2016，
  
  Published：19 October 2016
- 稿件说明：
移动端阅览
赵　宁,傅　深. 不同表型的乳腺癌干细胞研究现状及其临床应用价值[J]. 中国癌症杂志, 2016, 26(8): 699-703.

赵　宁, 傅　深. Recent advances in breast cancer stem cell phenotypes and clinical application[J]. China Oncology, 2016, 26(8): 699-703.
赵　宁,傅　深. 不同表型的乳腺癌干细胞研究现状及其临床应用价值[J]. 中国癌症杂志, 2016, 26(8): 699-703. DOI： 10.19401/j.cnki.1007-3639.2016.08.010.

赵　宁, 傅　深. Recent advances in breast cancer stem cell phenotypes and clinical application[J]. China Oncology, 2016, 26(8): 699-703. DOI： 10.19401/j.cnki.1007-3639.2016.08.010.

摘要

肿瘤干细胞理论认为肿瘤起源于小部分具有干细胞特性的肿瘤细胞。乳腺癌干细胞是乳腺癌细胞中极少数具有自我更新、多向分化潜能和高致瘤性的细胞亚群，与乳腺癌复发、侵袭转移、放化疗抵抗及上皮间质转化(epithelial-mesenchymal transition，EMT)等密切相关。就近年来乳腺癌干细胞的研究进展予以综述。

Abstract

The cancer stem cell theory suggests that cancer develops from a subset of tumor cells that possess characteristics of stem cells. Breast cancer stem cells comprise a sub-population

which possesses the capacity of selfrenewal and the potential for differentiation and high tumorigenicity. Evidence from both in vitro and in vivo studies demonstrates breast cancer stem cells are responsible for tumor relapse

invasion and metastasis

chemo- and radioresistance and epithelial-mesenchymal transition (EMT). Herein

this review highlighted the recent advances in breast cancer stem cells.

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