Research progress on long non-coding RNA in renal cell carcinoma

何安邦; 陈浩冬; 吕兆洁

doi:10.19401/j.cnki.1007-3639.2016.08.011

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Research progress on long non-coding RNA in renal cell carcinoma

更新时间：2025-12-31

- Research progress on long non-coding RNA in renal cell carcinoma
- China Oncology Vol. 26, Issue 8, Pages: 704-711(2016)
- 作者机构：
  
  安徽医科大学深圳市第二人民医院临床医学院泌尿外科,广东,深圳,518000
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2016.08.011
  CLC：
- Published Online：19 October 2016，
  
  Published：19 October 2016
- 稿件说明：
移动端阅览
何安邦,陈浩冬,吕兆洁,等. 肾癌相关长链非编码RNA研究进展[J]. 中国癌症杂志, 2016, 26(8): 704-711.

何安邦, 陈浩冬, 吕兆洁. Research progress on long non-coding RNA in renal cell carcinoma[J]. China Oncology, 2016, 26(8): 704-711.
何安邦,陈浩冬,吕兆洁,等. 肾癌相关长链非编码RNA研究进展[J]. 中国癌症杂志, 2016, 26(8): 704-711. DOI： 10.19401/j.cnki.1007-3639.2016.08.011.

何安邦, 陈浩冬, 吕兆洁. Research progress on long non-coding RNA in renal cell carcinoma[J]. China Oncology, 2016, 26(8): 704-711. DOI： 10.19401/j.cnki.1007-3639.2016.08.011.

摘要

长链非编码RNA(long non-coding RNA，lncRNA)是一类由RNA聚合酶Ⅱ转录及可变剪接而来、长度大于200个核苷酸、无蛋白编码功能的RNA分子。众多研究表明其在表观遗传学、转录等水平发挥重要的调控作用，且其异常表达与肾癌(renal cell carcinoma，RCC)的发生、发展、转移和预后等明显相关。旨在总结RCC相关lncRNA最新研究进展，浅析lncRNA在RCC发生、发展中的潜在分子机制，为RCC的预防、早期诊治及预后评估提供一种新的理论依据。

Abstract

Long non-coding RNA (lncRNA) is a class of RNA molecules

transcripted by RNA polymerase Ⅱ

which consists of more than 200 nucleotides and protein-coding function. Many studies have indicated that lncRNA plays an important role in epigenetics

transcription and post-translational processing. The abnormal expression of lncRNA significantly correlates with occurence

development

and metastasis of renal cell carcinoma (RCC) and prognosis of the patients with RCC. This paper summarizes the advances in the research on lncRNA in RCC to reveal the mechanisms of the disease at the molecular level

in order to provide new methods of prevention

diagnosis

treatment and prognostic assessment of RCC.

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