Dual-phase<sup>18</sup>F-FDG coincidence detection SPECT/CT imaging for differential diagnosis of pulmonary lesions

张　悦; 张遵城; 焦　妍

doi:10.19401/j.cnki.1007-3639.2016.10.010

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Dual-phase¹⁸F-FDG coincidence detection SPECT/CT imaging for differential diagnosis of pulmonary lesions

更新时间：2025-12-31

- Dual-phase¹⁸F-FDG coincidence detection SPECT/CT imaging for differential diagnosis of pulmonary lesions
- China Oncology Vol. 26, Issue 10, Pages: 866-869(2016)
- 作者机构：
  
  天津医科大学第二医院核医学科,天津,300211
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2016.10.010
  CLC：
- Published Online：17 November 2016，
  
  Published：17 November 2016
- 稿件说明：
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张　悦,张遵城,焦　妍,等. 双时相

张　悦, 张遵城, 焦　妍. Dual-phase¹⁸F-FDG coincidence detection SPECT/CT imaging for differential diagnosis of pulmonary lesions[J]. China Oncology, 2016, 26(10): 866-869.
张　悦,张遵城,焦　妍,等. 双时相 DOI： 10.19401/j.cnki.1007-3639.2016.10.010.

张　悦, 张遵城, 焦　妍. Dual-phase¹⁸F-FDG coincidence detection SPECT/CT imaging for differential diagnosis of pulmonary lesions[J]. China Oncology, 2016, 26(10): 866-869. DOI： 10.19401/j.cnki.1007-3639.2016.10.010.

摘要

背景与目的：葡萄糖肿瘤代谢显像已广泛应用于临床，而双时相显像技术能够更真实地反映肿瘤的葡萄糖代谢情况，更有助于良恶性的鉴别。探讨双时相

F-FDG符合线路SPECT/CT显像在肺占位性病变鉴别诊断中的应用价值。方法：胸部CT检查发现肺占位性病变患者28例。被检查者注射显像剂40~60 min后行胸部早期符合线路SPECT/CT显像，延迟显像于静脉注射显像剂后2~3 h进行。计算早期及延时两次显像病灶部位(T)与正常部位(N)的放射性计数比值T

及T

，并计算T/N的变化率ΔT/N。利用受试者工作特征曲线(receiver operating characteristic curve，ROC)确定T

、T

及ΔT/N的诊断阈值，应用曲线下面积(area under the curve，AUC)分别评价早期显像和双时相显像的诊断效能。结果：早期显像T

的诊断阈值为2.650，AUC为0.767，诊断肺癌的灵敏度为83.3%，特异度为30.0%，准确度为64.3%。延时显像T2/N2的诊断阈值为3.140，AUC为0.847，诊断肺癌的灵敏度为94.4%，特异度为60.0%，准确度为82.1%。ΔT/N的诊断阈值为16.9%，AUC为0.950，诊断肺癌的灵敏度为88.5%，特异度为71.4%，准确度为86.2%。结论：双时相

F-FDG符合线路SPECT/CT显像对肺占位性病变的鉴别诊断与常规一次显像相比有较高的准确度和特异度，但仍存在假阳性，应结合患者CT图像特征及临床病史综合分析。

Abstract

Background and purpose: Although FDG tumor imaging has been applied in clinic widely

dual-phase imaging can provide much more information about the FDG uptaking of pulmonary lesions. The purpose of the study was to evaluate the usefulness of dual-phase

F-FDG coincidence detection SPECT/CT imaging in the differential diagnosis of the pulmonary lesions. M

ethods: There were 28 patients with pulmonary lesions which were detected by CT. All the patients undertook the SPECT/CT imaging at 2 time-phases respectively: early imaging at 40-60 min and delayed imaging at 2-3 h after the intravenous injection of FDG. Data processing: calculating the radio of T and N in early and delayed imaging respectively; T: The radioactive count of the lesions; N: The radioactive count of the normal tissue; and the change rate: ΔT/N. ROC was used to find out the threshold of T

及ΔT/N in the differential diagnosis between benign and malignant lesions. AUC was used to evaluate the diagnosis value of the dual-phase and single-phase imaging. Results: The threshold of T1/N1 in early imaging was 2.65

whereas AUC was 0.767. The sensitivity

specificity and accuracy were 83.3%

30% and 64.3%

respectively. The threshold of T

in delayed imaging was 3.14

whereas AUC was 0.847. The sensitivity

specificity and accuracy were 94.4%

60.0% and 82.1%

respectively. The threshold of ΔT/N in delayed imaging was 16.9%

whereas AUC is 0.950. The sensitivity

specificity and accuracy were 88.5%

71.4% and 86.2%

respectively. Conclusion: Dual-phase

F-FDG coincidence detection SPECT/CT imaging has much higher accuracy and specificity. However it still has false positivity

and should be analyzed with CT and clinical history.

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Dual-phase18F-FDG coincidence detection SPECT/CT imaging for differential diagnosis of pulmonary lesions

DOI：10.19401/j.cnki.1007-3639.2016.10.010

摘要

Abstract

关键词

Keywords

references

Dual-phase¹⁸F-FDG coincidence detection SPECT/CT imaging for differential diagnosis of pulmonary lesions