The association between metabolic syndrome and renal cell carcinoma

李　慧; 王弘恺; 顾伟杰

doi:10.19401/j.cnki.1007-3639.2016.10.011

您当前的位置：

首页 >

文章列表页 >

The association between metabolic syndrome and renal cell carcinoma

更新时间：2025-12-31

- The association between metabolic syndrome and renal cell carcinoma
- China Oncology Vol. 26, Issue 10, Pages: 870-874(2016)
- 作者机构：
  
  1. 第二军医大学附属长海医院内分泌科,上海,200433
  2. 复旦大学附属肿瘤医院泌尿外科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2016.10.011
  CLC：
- Published Online：17 November 2016，
  
  Published：17 November 2016
- 稿件说明：
移动端阅览
李　慧,王弘恺,顾伟杰,等. 代谢综合征和肾细胞癌的相关性研究[J]. 中国癌症杂志, 2016, 26(10): 870-874.

李　慧, 王弘恺, 顾伟杰. The association between metabolic syndrome and renal cell carcinoma[J]. China Oncology, 2016, 26(10): 870-874.
李　慧,王弘恺,顾伟杰,等. 代谢综合征和肾细胞癌的相关性研究[J]. 中国癌症杂志, 2016, 26(10): 870-874. DOI： 10.19401/j.cnki.1007-3639.2016.10.011.

李　慧, 王弘恺, 顾伟杰. The association between metabolic syndrome and renal cell carcinoma[J]. China Oncology, 2016, 26(10): 870-874. DOI： 10.19401/j.cnki.1007-3639.2016.10.011.

摘要

背景与目的：代谢综合征(metabolic syndrome，MS)与肾细胞癌(renal cell carcinoma，RCC)的发生、发展有何联系尚无相关研究。该研究拟探究MS与RCC发生率及恶性程度的相关性。方法：入组398例RCC患者(透明细胞癌350例，XP11.2易位RCC 5例，乳头状RCC 16例，嫌色细胞癌27例)。160名健康体检者及32例良性肾肿瘤患者(血管平滑肌脂肪瘤21例，嗜酸细胞腺瘤8例，后肾腺瘤3例)作为对照组，计算不同人群MS的患病率，比较MS对RCC发生率及恶性程度的影响。结果：透明细胞癌患者相对于正常人群血压、体质指数(body mass index，BMI)和腰围的差异有统计学意义(P0.05)。透明细胞癌的患者同时发生MS的概率为48%、乳头状细胞癌为33%、嫌色细胞癌为26%、XP11.2易位RCC为0%、血管平滑肌脂肪瘤为17%，而正常体检者发生MS的概率为25%。该研究人群中，MS患者同时患透明细胞癌的概率远高于非MS的患者，而这种差异并未在其他恶性肿瘤中明确体现。病理级别较高的透明细胞癌患者MS发生率较低。结论：MS患者更易发生RCC尤其是肾透明细胞癌。高Furhman分级的患者合并MS的可能性下降，提示对于高分级的患者，RCC的发生可能与代谢性因素无关。

Abstract

Background and purpose: The association between metabolic syndrome (MS) and renal cell carcinoma (RCC) is still unknown. The aim of this study was to elucidate how MS correlates with the prevalence and malignancy of RCC. Methods: This study enrolled 398 RCC patients (350 clear cell RCC patients

5 XP11.2 translocation RCC patients

16 papillary RCC patients and 27 chromophobe RCC patients)

160 normal persons

and 32 benign renal tumor patients. The metabolic status of the patients was assessed

and the link between MS and the prevalence or malignancy of RCC was calculated. Results: Clear cell RCC patients had significantly higher rates of hypertension

higher body mass index (BMI) and longer waist circumference. Forty-eight percent clear cell RCC patients had MS

while the number was 33% for papillary RCC

26% for chromophobe RCC

0% for XP11.2

17% for AML

and 25% for normal people. MS patients had significant higher rates of having clear cell RCC than no-MS patients

however this kind of difference was not seen in other types of RCC. Clear cell RCC patients with higher Furhman grade had lower rates of MS. Conclusion: Patients with MS are more likely to develop clear cell RCC. Patients with high Furhman grade tumors have low MS rates

indicating that high grade tumor may have other originating mechanisms other than metabolic disorders.

关键词

Keywords

references

Views

1743

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Advances in the research, diagnosis and treatment of renal cell carcinoma in 2022

Evaluating the change of fatty acid synthesis in renal cell carcinoma by 18F-FAC microPET/CT imaging

A comparative study of four methods of establishing orthotopic human renal cell carcinoma models in nude mice

Application of DWI with various b values in diagnosis of clear cell renal cell carcinoma Fuhrman grades

Research and progress of diffusion-weighted magnetic resonance imaging in the diagnosis of renal tumor

Related Author

Dingwei YE

Hailiang ZHANG

Guohai SHI

Yuanyuan QU

Shiqi YE

Jiaqi SU

艾合太木江·安外尔

Shuxuan ZHU

Related Institution

Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University

复旦大学附属肿瘤医院核医学科，复旦大学上海医学院肿瘤学系，复旦大学生物医学

影像研究中心，上海分子影像探针工程技术研究中心

复旦大学核物理与离子束应用教育部重点实验室

上海交通大学医学院附属仁济医院肾脏科

AI问答

⁰