The progress of the research on the relationship between stanniocalcins and cancers

杨舒雯; 马　奔; 周　力

doi:10.19401/j.cnki.1007-3639.2016.10.012

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The progress of the research on the relationship between stanniocalcins and cancers

更新时间：2025-12-31

- The progress of the research on the relationship between stanniocalcins and cancers
- China Oncology Vol. 26, Issue 10, Pages: 875-880(2016)
- 作者机构：
  
  复旦大学附属肿瘤医院头颈外科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2016.10.012
  CLC：
- Published Online：17 November 2016，
  
  Published：17 November 2016
- 稿件说明：
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杨舒雯,马　奔,周　力,等. 斯钙素的生物学特征及其与人体肿瘤关系研究进展[J]. 中国癌症杂志, 2016, 26(10): 875-880.

杨舒雯, 马　奔, 周　力. The progress of the research on the relationship between stanniocalcins and cancers[J]. China Oncology, 2016, 26(10): 875-880.
杨舒雯,马　奔,周　力,等. 斯钙素的生物学特征及其与人体肿瘤关系研究进展[J]. 中国癌症杂志, 2016, 26(10): 875-880. DOI： 10.19401/j.cnki.1007-3639.2016.10.012.

杨舒雯, 马　奔, 周　力. The progress of the research on the relationship between stanniocalcins and cancers[J]. China Oncology, 2016, 26(10): 875-880. DOI： 10.19401/j.cnki.1007-3639.2016.10.012.

摘要

斯钙素(stanniocalcin，STC)是一种糖蛋白激素，由鱼类独有的内分泌腺斯坦尼小体所分泌。在哺乳动物中，也存在STC样蛋白，分别命名为STC-1和STC-2，通过肾脏和胃肠道来调节钙和磷酸盐的代谢，STC-1与鱼类STC氨基酸序列显示高度同源性(约50%)，STC-2则较低，有35%左右的氨基酸呈同源性。一些研究已发现它们的细胞定位、基因结构在不同的生理和病理情况下的表达，为阐明哺乳动物的STC功能提供线索。此外，STC-1和STC-2在众多肿瘤细胞系中有表达，提示哺乳动物STC具有除矿物质代谢外的多种生物学功能。

Abstract

Stanniocalcin (STC) was first found as a calcium- and phosphate-regulating hormone produced in bony fish by the corpuscles of Stannius. In mammals

the homolog STC-1 displays a relative high amino acid sequence identity (nearly 50%) with fish STC

and STC-2 has a lower identity (nearly 35%) with STC-1 and fish STC. Both STC-1 and STC-2 are expressed in a variety of tissues. The functions of STC have not been understood. But some findings have been reported on their cellular localization

gene structure

and expression in different physiological and pathological conditions

which will be clues in elucidating the functions of STC in mammals. Moreover

STC-1 and STC-2 are expressed in many tumor cell lines

suggesting other biological functions of STC in mammals other than mineral metabolism.

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