Relationship of SRC pY416 expression in hepatocellular carcinoma with clinical parameters and intrahepatic metastasis

吴　维; 崔培元; 鲁　正

doi:10.19401/j.cnki.1007-3639.2017.02.006

您当前的位置：

首页 >

文章列表页 >

Relationship of SRC pY416 expression in hepatocellular carcinoma with clinical parameters and intrahepatic metastasis

更新时间：2025-12-31

- Relationship of SRC pY416 expression in hepatocellular carcinoma with clinical parameters and intrahepatic metastasis
- China Oncology Vol. 27, Issue 2, Pages: 115-120(2017)
- 作者机构：
  
  蚌埠医学院第一附属医院肝胆外科,安徽,蚌埠,233000
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2017.02.006
  CLC：
- Published Online：22 March 2017，
  
  Published：22 March 2017
- 稿件说明：
移动端阅览
吴　维,崔培元,鲁　正,等. SRC pY416在肝细胞癌中的表达与临床相关参数及肝内转移的关系[J]. 中国癌症杂志, 2017, 27(2): 115-120.

吴　维, 崔培元, 鲁　正. Relationship of SRC pY416 expression in hepatocellular carcinoma with clinical parameters and intrahepatic metastasis[J]. China Oncology, 2017, 27(2): 115-120.
吴　维,崔培元,鲁　正,等. SRC pY416在肝细胞癌中的表达与临床相关参数及肝内转移的关系[J]. 中国癌症杂志, 2017, 27(2): 115-120. DOI： 10.19401/j.cnki.1007-3639.2017.02.006.

吴　维, 崔培元, 鲁　正. Relationship of SRC pY416 expression in hepatocellular carcinoma with clinical parameters and intrahepatic metastasis[J]. China Oncology, 2017, 27(2): 115-120. DOI： 10.19401/j.cnki.1007-3639.2017.02.006.

摘要

背景与目的：肝细胞癌(hepatocellular carcinoma，HCC)是最常见的恶性肿瘤之一，肝内复发转移是影响其中期生存率的主要因素，因此，转移标志物的寻找至关重要。该研究探讨HCC中肉瘤酪氨酸激酶磷酸化Tyr416(tyrosine kinase phosphorylation Tyr416 of sarcoma，SRC pY416)的表达与临床相关参数及肝内复发转移的关系。方法：采用免疫组织化学法和蛋白［质］印迹法(Western blot)检测112例HCC组织、40例相应癌旁正常肝脏组织中SRC pY416的表达，化学发光法检测患者乙型肝炎病毒DNA(hepatitis B virus-DNA，HBV-NDA)和甲胎蛋白(alpha fetoprotein，AFP)，随访12个月，分析SRC pY416与HCC患者临床相关参数及预后的关系。结果：SRC pY416在HCC组织中的表达(65.40±15.69)均高于癌旁正常肝脏组织(11.25±2.73，P＜0.001)。SRC pY416的表达与患者年龄、肝硬化、包膜完整、分化程度、HBV-NDA及AFP均存在相关性(P＜0.01)。单因素分析显示，HCC患者术后12个月肝内复发转移与患者年龄、AFP表达、分化程度、是否携带HBV及SRC pY416蛋白表达有关(P＜0.01)，多因素分析显示，SRC pY416蛋白表达是HCC患者12个月肝内复发转移的独立危险因素。结论：SRC pY416可能在HCC转移中起重要作用，有望成为HCC肝内转移的分子标志物。

Abstract

Background and purpose: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Intrahepatic recurrence is the main factor affecting its medium-term survival rate. Therefore

the search for the markers of metastasis is essential. This study aimed to evaluate the relationship of expression of tyrosine kinase phosphorylation Tyr416 of sarcoma (SRC pY416) in HCC with clinical parameters and prognosis. Methods: Immunohistochemical method and Western blot were used to detect the expression of non-receptor tyrosine kinase (SRC pY416) in 112 cases of HCC tissues and 40 cases of corresponding cancer adjacent normal liver tissues. Hepatitis B virus (HBV) DNA and alpha fetoprotein (AFP) in patients were detected with chemiluminescence. In the 12 months Follow-up of the study

the association between SRC pY416 expression and clinical parameters was analyzed. Results: SRC pY416 expressions in HCC (65.40±15.69) were higher than those in cancer adjacent normal liver tissues (11.25±2.73

P0.001). The expressions of SRC pY416 were all associated with the age

the liver cirrhosis

the complete capsule

the tumor differentiation

the HBV DNA and the AFP value of the patients (P0.01). 12 months after operation

single factor analysis showed that the recurrence was associated with the tumor differentiation

the HBV DNA

the AFP value and the expression of SRC pY416 of the patient (P0.01). Multivariate analysis showed that the expression of SRC pY416 was an independent prognostic factor for recurrence and metastasis in patients with HCC in 12 months. Conclusion: SRC pY416 may play an important role in the metastasis of HCC. The expression of SRC pY416 may be the marker for HCC liver metastasis.

关键词

Keywords

references

Views

1934

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

PARP1 promotes the progression of hepatocellular carcinoma by regulating expression of POU2F2

Significance of infiltration of M1 tumor-associated macrophages in hepatocellular carcinoma

Progress in research, diagnosis, and treatment of hepatocellular carcinoma in 2022

Mechanism of LINC00601 in regulating sensitivity of hepatocellular carcinoma cells to oxaliplatin chemotherapy

Plasma exosomal CD48 protein as a candidate diagnostic biomarker for hepatocellular carcinoma

Related Author

Ziqiang WEN

Junliang LAN

Bo ZHOU

Qiwei XU

Feng XIAO

Tonglin XU

Lin ZHU

Jingwen XIAO

Related Institution

Department of Hepatobiliary Surgery, Linfen People’s Hospital, The Seventh Clinical Medical College of Shanxi Medical University

Clinical Medicine, Major of Medical College Nantong University

Department of Surgery, the Third People’s Hospital of Nantong, Affiliated Nantong Hospital Three of Nantong University

Department of Pathology, the Third People's Hospital of Nantong, Affiliated Nantong Hospital Three of Nantong University

Liver Cancer Institute, Zhongshan Hospital, Fudan University

AI问答

⁰