Research progress on WNT/β-catenin signaling pathway and miRNA in primary lung cancer

陆周一; 陈晓峰

doi:10.19401/j.cnki.1007-3639.2017.02.012

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Research progress on WNT/β-catenin signaling pathway and miRNA in primary lung cancer

更新时间：2025-12-31

- Research progress on WNT/β-catenin signaling pathway and miRNA in primary lung cancer
- China Oncology Vol. 27, Issue 2, Pages: 151-155(2017)
- 作者机构：
  
  1. 同济大学附属上海市肺科医院胸外科,上海,200092
  2. 复旦大学附属华山医院胸心外科,上海,200040
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2017.02.012
  CLC：
- Published Online：22 March 2017，
  
  Published：22 March 2017
- 稿件说明：
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陆周一,陈晓峰. WNT/β-catenin信号通路与miRNA在原发性肺癌中的研究进展[J]. 中国癌症杂志, 2017, 27(2): 151-155.

陆周一, 陈晓峰. Research progress on WNT/β-catenin signaling pathway and miRNA in primary lung cancer[J]. China Oncology, 2017, 27(2): 151-155.
陆周一,陈晓峰. WNT/β-catenin信号通路与miRNA在原发性肺癌中的研究进展[J]. 中国癌症杂志, 2017, 27(2): 151-155. DOI： 10.19401/j.cnki.1007-3639.2017.02.012.

陆周一, 陈晓峰. Research progress on WNT/β-catenin signaling pathway and miRNA in primary lung cancer[J]. China Oncology, 2017, 27(2): 151-155. DOI： 10.19401/j.cnki.1007-3639.2017.02.012.

摘要

WNT/β-catenin信号通路在细胞增殖、分化和器官发育中起着重要作用。WNT/β-catenin信号通路的异常活化及与该信号通路相关的miRNA异常调节与原发性肺癌的发生、发展有着密切联系。因此深入研究肺癌中WNT/β-catenin信号通路的调控机制，阐明miRNA与该通路成分间的相互作用可能为发现新的肺癌药物治疗靶点提供思路。本文就原发性肺癌中的WNT/β-catenin信号通路和miRNA及以两者为靶点的肺癌治疗研究进行综述。

Abstract

The WNT/β-catenin signaling pathway plays a critical role in cellular proliferation

differentiation and organogenesis. Aberration activation of WNT/β-catenin pathway and dysregulation of miRNA related with this pathway are involved in oncogenesis and tumor progression in primary lung cancer. Understanding the mechanism of the WNT/β-catenin signaling pathway and illuminating the interaction between miRNA and the members of this pathway may improve the perspectives of using these molecules as potential therapeutic targets for primary lung cancer. This review focused on the participation of the WNT/β-catenin signaling pathway and miRNA in lung cancer and discussion of potential targets for this malignancy therapy in the future.

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