Postoperative differences in clinical characteristics between adenocarcinoma and other types of nonsmall cell lung cancer and analysis of prognostic factors of adenocarcinoma treated with surgery

田希贵; 刘德森; 汪元玉

doi:10.19401/j.cnki.1007-3639.2017.03.011

您当前的位置：

首页 >

文章列表页 >

Postoperative differences in clinical characteristics between adenocarcinoma and other types of nonsmall cell lung cancer and analysis of prognostic factors of adenocarcinoma treated with surgery

更新时间：2025-12-31

- Postoperative differences in clinical characteristics between adenocarcinoma and other types of nonsmall cell lung cancer and analysis of prognostic factors of adenocarcinoma treated with surgery
- China Oncology Vol. 27, Issue 3, Pages: 227-232(2017)
- 作者机构：
  
  广西医科大学附属肿瘤医院胸外科,广西,南宁,530021
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2017.03.011
  CLC：
- Published Online：12 April 2017，
  
  Published：12 April 2017
- 稿件说明：
移动端阅览
田希贵,刘德森,汪元玉,等. 腺癌与其他类型非小细胞肺癌术后临床特点的差异及预后因素分析[J]. 中国癌症杂志, 2017, 27(3): 227-232.

田希贵, 刘德森, 汪元玉. Postoperative differences in clinical characteristics between adenocarcinoma and other types of nonsmall cell lung cancer and analysis of prognostic factors of adenocarcinoma treated with surgery[J]. China Oncology, 2017, 27(3): 227-232.
田希贵,刘德森,汪元玉,等. 腺癌与其他类型非小细胞肺癌术后临床特点的差异及预后因素分析[J]. 中国癌症杂志, 2017, 27(3): 227-232. DOI： 10.19401/j.cnki.1007-3639.2017.03.011.

田希贵, 刘德森, 汪元玉. Postoperative differences in clinical characteristics between adenocarcinoma and other types of nonsmall cell lung cancer and analysis of prognostic factors of adenocarcinoma treated with surgery[J]. China Oncology, 2017, 27(3): 227-232. DOI： 10.19401/j.cnki.1007-3639.2017.03.011.

摘要

背景与目的：近年来肺腺癌已成为肺癌最常见的病理类型，且呈逐年上升的趋势。该研究探讨肺腺癌与其他类型非小细胞肺癌(non-small cell lung cancer，NSCLC)术后临床特点的差异及影响其术后预后的因素。方法：选取广西医科大学附属肿瘤医院2005年1月1日—2014年12月31日经手术治疗的NSCLC患者的病历资料，比较腺癌与其他类型癌临床特点的差异，并运用log-rank方法及Cox比例风险回归模型分析影响腺癌术后预后的因素。结果：451例腺癌患者中，男性与女性比例为1.29∶1，平均发病年龄为56.02岁，淋巴结转移率为53.22%(240/451)，中位生存期为44个月；其与其他类型NSCLC在性别比例(P0.001)、平均发病年龄(P=0.039)、淋巴结转移率(P=0.012)和中位生存期(P0.001)方面差异均有统计学意义。多因素分析显示：PTNM分期(P0.001)、性别(P=0.032)、术前合并糖尿病(P=0.019)、隆突下淋巴结转移(P=0.013)、淋巴结转移组数(P0.001)、术后化疗(P=0.040)或靶向治疗(P0.001)是影响腺癌术后预后的独立因素。结论：与其他类型NSCLC相比，腺癌具有女性发病率高、平均发病年龄较低、淋巴结转移率较高和预后较差的特点；PTNM分期、性别、术前合并糖尿病、隆突下淋巴结转移、淋巴结转移组数、术后化疗或靶向治疗是影响其术后预后的重要因素，可为评估预后提供参考。

Abstract

Background and purpose: Adenocarcinoma has become the most common histological type of lung cancer in recent years

and there is an increasing trend. This study aimed to investigate postoperative differences in clinical characteristics between adenocarcinoma and other types of non-small cell lung cancer (NSCLC) and prognostic factors of adenocarcinoma treated with surgery

and to provide a reference for the prevention and treatment of lung adenocarcinoma. Methods: The medical records of patients with NSCLC treated with surgery were selected from Jan. 2005 to Dec. 2014 at the Affiliated Tumor Hospital of Guangxi Medical University. This study compared the differences in clinical characteristics between adenocarcinoma and other types of NSCLC

and analyzed the influence of prognostic factors of lung adenocarcinoma with log-rank test and COX model. Results: With 451 cases of adenocarcinoma

the gender ratio was 1.29∶1

the average age was 56.02 years old

the lymph node metastasis rate was 53.22% (240/451)

and the median survival time was 44 months. There were statistical differences between adenocarcinoma and other types of NSCLC in gender ratio (P0.001)

average age (P=0.039)

lymph node metastasis rate (P=0.012)

and median survival time (P0.001). In multivariate analysis

PTNM stage (P0.001)

gender (P=0.032)

preoperative diabetes (P=0.019)

subcarinal lymph node metastasis (P=0.013)

number of lymph node metastasis (P0.001)

postoperative chemotherapy (P=0.040) or targeted therapy after surgery (P0.001) were independent prognostic factors. Conclusion: Compared with other types of NSCLC

adenocarcinoma showed the characteristics of higher incidence of constituent ratio in women

lower average age

higher rate of lymph node metastasis and poor prognosis. PTNM stage

gender

preoperative diabetes

subcarinal lymph node metastasis

number of lymph node metastasis

postoperative chemotherapy or targeted therapy are important influencing factors that can affect the prognosis of adenocarcinoma following the surgical procedure.

关键词

Keywords

references

Views

2657

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression, prognostic value of CBX3 in lung adenocarcinoma and its effect on biological behavior of cancer cells

Clinical characteristics and therapeutic status of primary Waldeyer’s ring non-Hodgkin’s lymphoma

Clinical treatment and prognostic analysis of rectal small cell carcinoma：A report of 16 cases

Clinicopathologic features of SMARCA4-deficient pulmonary malignant tumor with an emphasis on the prognosis

Treatment strategies and prognostic analysis of 87 patients with salivary duct carcinoma: a retrospective cohort study

Related Author

Qinghua HOU

Yanfeng ZHONG

Linzhuang LIU

Liusheng WU

Jixian LIU

李春艳

郭　晔

许勇飞

Related Institution

School of Clinical Medicine, Weifang Medical College

Department of Thoracic Surgery, Shenzhen Hospital, Peking University

Central Laboratory of Shenzhen Hospital, Peking University

复旦大学附属肿瘤医院肿瘤内科，复旦大学上海医学院肿瘤学系

郑州大学附属肿瘤医院内科

AI问答

⁰