Research progress on exosome-derived non-coding RNA in digestive system malignancy

于淑林; 陈　震

doi:10.19401/j.cnki.1007-3639.2017.04.010

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Research progress on exosome-derived non-coding RNA in digestive system malignancy

更新时间：2025-12-31

- Research progress on exosome-derived non-coding RNA in digestive system malignancy
- China Oncology Vol. 27, Issue 4, Pages: 297-303(2017)
- 作者机构：
  
  复旦大学附属肿瘤医院中西医结合科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2017.04.010
  CLC：
- Published Online：05 May 2017，
  
  Published：05 May 2017
- 稿件说明：
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于淑林,陈　震. 外泌体源性非编码RNA在消化系统恶性肿瘤中的研究进展及展望[J]. 中国癌症杂志, 2017, 27(4): 297-303.

于淑林, 陈　震. Research progress on exosome-derived non-coding RNA in digestive system malignancy[J]. China Oncology, 2017, 27(4): 297-303.
于淑林,陈　震. 外泌体源性非编码RNA在消化系统恶性肿瘤中的研究进展及展望[J]. 中国癌症杂志, 2017, 27(4): 297-303. DOI： 10.19401/j.cnki.1007-3639.2017.04.010.

于淑林, 陈　震. Research progress on exosome-derived non-coding RNA in digestive system malignancy[J]. China Oncology, 2017, 27(4): 297-303. DOI： 10.19401/j.cnki.1007-3639.2017.04.010.

摘要

外泌体是纳米级、双层膜的囊泡，由多种细胞分泌，广泛存在于多种体液中。外泌体中含有RNA和蛋白质等多种活性物质，在细胞物质间和信号转导中起重要作用。非编码RNA具有重要的基因表达调控功能，在多种肿瘤的发生、发展过程中起重要作用。外泌体源性非编码RNA的研究是目前新的研究热点，现就外泌体及外泌体源性非编码RNA在消化系统恶性肿瘤中的研究进展进行综述。

Abstract

Exosome is a kind of biological membrane structure at nanometer level. It is secreted by various cells and widely distributed in most body fluids. Biological active substances

including non-coding RNAs and proteins

have been identified in the exosomes. Exosome may be involved in cell-to-cell substance transporting and signaling. Non-coding RNAs have important function of regulating gene expression and also play key roles in the occurrence and development of many cancers. Research on exosome-derived non-coding RNA is a new hotspot at present. In this paper

we will review research progress on exosome and exosome-derived non-coding RNA in digestive system malignancy.

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