Research progress of DNA methylation in thyroid cancer

曹一鸣; 朱永学

doi:10.19401/j.cnki.1007-3639.2017.04.011

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Research progress of DNA methylation in thyroid cancer

更新时间：2025-12-31

- Research progress of DNA methylation in thyroid cancer
- China Oncology Vol. 27, Issue 4, Pages: 304-311(2017)
- 作者机构：
  
  复旦大学附属肿瘤医院头颈外科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2017.04.011
  CLC：
- Published Online：05 May 2017，
  
  Published：05 May 2017
- 稿件说明：
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曹一鸣,朱永学 . 甲状腺癌的DNA甲基化研究进展[J]. 中国癌症杂志, 2017, 27(4): 304-311.

曹一鸣, 朱永学. Research progress of DNA methylation in thyroid cancer[J]. China Oncology, 2017, 27(4): 304-311.
曹一鸣,朱永学 . 甲状腺癌的DNA甲基化研究进展[J]. 中国癌症杂志, 2017, 27(4): 304-311. DOI： 10.19401/j.cnki.1007-3639.2017.04.011.

曹一鸣, 朱永学. Research progress of DNA methylation in thyroid cancer[J]. China Oncology, 2017, 27(4): 304-311. DOI： 10.19401/j.cnki.1007-3639.2017.04.011.

摘要

DNA甲基化是一种重要的表观遗传学改变，在肿瘤的发病、诊断、预后评估及治疗中都有重要的临床意义。甲状腺癌是临床最常见的内分泌系统恶性肿瘤，目前国内外关于甲状腺癌的DNA甲基化的研究相对较少，该文总结近年来甲状腺癌领域相关的基因甲基化研究，就甲状腺癌的DNA甲基化研究进展进行综述。

Abstract

DNA methylation is an important epigenetic modification. Evaluating the status of DNA methylation could be useful for diagnosis

prognostic evaluation and predicting the risk of cancer. Thyroid cancer is the most prevalent endocrine malignancy in humans. Growing evidence shows that epigenetic abnormalities participate with genetic alterations in carcinogenesis of thyroid cancer. This article reviewed the recent research progress of DNA methylation in thyroid cancer.

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