Research on the relationship between fructose-1, 6-bisphosphatase and chemosensitivity of ovarian carcinoma

李浩然; 李梦娇; 刘　霏

doi:10.19401/j.cnki.1007-3639.2017.05.004

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Research on the relationship between fructose-1, 6-bisphosphatase and chemosensitivity of ovarian carcinoma

更新时间：2025-12-31

- Research on the relationship between fructose-1, 6-bisphosphatase and chemosensitivity of ovarian carcinoma
- China Oncology Vol. 27, Issue 5, Pages: 340-344(2017)
- 作者机构：
  
  复旦大学附属肿瘤医院妇瘤科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2017.05.004
  CLC：
- Published Online：14 June 2017，
  
  Published：14 June 2017
- 稿件说明：
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李浩然,李梦娇,刘　霏,等. 糖代谢中关键酶果糖双磷酸酶-1与卵巢癌化疗敏感性关系的研究[J]. 中国癌症杂志, 2017, 27(5): 340-344.

李浩然, 李梦娇, 刘　霏. Research on the relationship between fructose-1, 6-bisphosphatase and chemosensitivity of ovarian carcinoma[J]. China Oncology, 2017, 27(5): 340-344.
李浩然,李梦娇,刘　霏,等. 糖代谢中关键酶果糖双磷酸酶-1与卵巢癌化疗敏感性关系的研究[J]. 中国癌症杂志, 2017, 27(5): 340-344. DOI： 10.19401/j.cnki.1007-3639.2017.05.004.

李浩然, 李梦娇, 刘　霏. Research on the relationship between fructose-1, 6-bisphosphatase and chemosensitivity of ovarian carcinoma[J]. China Oncology, 2017, 27(5): 340-344. DOI： 10.19401/j.cnki.1007-3639.2017.05.004.

摘要

背景与目的：上皮性卵巢癌是女性生殖系统恶性肿瘤中死亡率最高的肿瘤。化疗期间耐药的产生是卵巢癌死亡率高的主要原因。果糖双磷酸酶-1(fructose-1

6-bisphosphatase，FBP1)是糖代谢过程中的关键酶。FBP1用于催化1

6 -二磷酸果糖水解为6-磷酸果糖和磷酸盐，从而抑制细胞的糖酵解。该研究旨在探讨FBP1与卵巢癌化疗敏感性关系。方法：采用免疫组织化学方法检测209例卵巢癌患者标本中FBP1蛋白的表达水平及其与卵巢癌患者化疗敏感性的关系。结果：在209例卵巢癌组织中，FBP1的阳性表达率为49.3%(103/209)，FBP1表达阳性组患者生存期长于阴性组，二者之间差异有统计学意义(42.6个月 vs 62.1个月，P=0.003)，并且FBP1表达与化疗敏感性相关(P=0.007)。结论：糖代谢中关键酶基因FBP1的表达可能与卵巢癌对化疗的敏感性有关，可作为化疗敏感性及预后判断的重要指标。

Abstract

Background and purpose: Epithelial ovarian carcinoma is the most malignant tumor in female reproductive system because of its resistance to chemotherapy. Fructose-1

6-bisphosphatase (FBP1) is a rate-limiting enzyme in gluconeogenesis used to catalyze the hydrolysis of fructose-1

6-bisphosphate to fructose-6-phosphate and inorganic phosphate

thereby inhibiting the effect of glycolysis in tumor cells. This study aimed to investigate the association between the expression of FBP1 and chemosensitivity. Methods: The expression level of FBP1 in ovarian cancer patients was measured by immunohistochemistry. Results: According to the results of immunohistochemistry in 209 ovarian carcinoma specimens

the percentage of positive FBP1 expression was about 49.3% (103/209). Loss of FBP1 was a negative factor of survival (42.6 months vs 62.1 months

P=0.003). Besides

patients who were sensitive to chemotherapy displayed significantly higher scores of FBP1 expression than patients who were resistant to therapy (P=0.007). Conclusion: The rate-limiting enzyme FBP1 in gluconeogenesis can be used as a biomarker for predicting the chemoresistance and prognosis of ovarian cancer patients.

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