Effects of<em>BRAF</em>V600E mutation on oncogenesis and prognosis in papillary thyroid cancer

张婷婷; 渠　宁; 史荣亮

doi:10.19401/j.cnki.1007-3639.2017.06.011

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Effects ofBRAFV600E mutation on oncogenesis and prognosis in papillary thyroid cancer

更新时间：2025-12-31

- Effects ofBRAFV600E mutation on oncogenesis and prognosis in papillary thyroid cancer
- China Oncology Vol. 27, Issue 2, Pages: 145-150(2017)
- 作者机构：
  
  复旦大学附属肿瘤医院头颈外科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2017.06.011
  CLC：
- Published Online：22 March 2017，
  
  Published：22 March 2017
- 稿件说明：
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张婷婷,渠　宁,史荣亮,等.

张婷婷, 渠　宁, 史荣亮. Effects ofBRAFV600E mutation on oncogenesis and prognosis in papillary thyroid cancer[J]. China Oncology, 2017, 27(2): 145-150.
张婷婷,渠　宁,史荣亮,等. DOI： 10.19401/j.cnki.1007-3639.2017.06.011.

张婷婷, 渠　宁, 史荣亮. Effects ofBRAFV600E mutation on oncogenesis and prognosis in papillary thyroid cancer[J]. China Oncology, 2017, 27(2): 145-150. DOI： 10.19401/j.cnki.1007-3639.2017.06.011.

摘要

甲状腺乳头状癌(papillary thyroid cancer，PTC)是甲状腺癌最常见的病理类型。PTC通常预后良好，但近年来甲状腺癌的发病率逐年攀升。随着患病人数的不断增多，中晚期难治性甲状腺癌患者不再少见。因此，越发庞大的甲状腺癌患者群体的管理与诊治已成为巨大的考验。BRAF V600E基因突变是乳头状癌经典DNA相关标志物，目前已被广泛应用于甲状腺癌的术前诊断和预后评估，并且作为潜在的治疗靶点受到越来越多的关注。因此，正确全面的了解BRAF V600E基因突变可以帮助我们对PTC的发生、发展及生物学行为有更进一步的了解，并为PTC患者管理方式与治疗策略提供新的方向。

Abstract

Papillary thyroid cancer (PTC) is the most common pathological type of thyroid cancer

always with favorable prognosis. However

the incidence of thyroid cancer recently appeared to be an increasing trend. Because of the increased amount of patients

refractory thyroid cancer was not rare anymore. Hence

we are facing a big challenge how to manage and treat the increasing number of patients. BRAF V600E mutation is a classic DNA-relative biomarker for PTC

and widely used in preoperative diagnosis and evaluation of prognosis. As a potential therapeutic target

it attracted more and more attention. Recognizing BRAF V600E mutation can help us to know oncogenesis and biological behavior of PTC better and provide profitable treatment and management.

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Related Institution

Department of Thoracic Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

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Department of Pathology, Wuxi Second People’s Hospital

Department of Pathology, Affiliated Hospital of Nantong University

Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Malignant Tumors

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Effects ofBRAFV600E mutation on oncogenesis and prognosis in papillary thyroid cancer

DOI：10.19401/j.cnki.1007-3639.2017.06.011

摘要

Abstract

关键词

Keywords

references