The value of serum sialic acid levels detection in ovarian cancer

胡宏峰; 卢仁泉; 胡　娟

doi:10.19401/j.cnki.1007-3639.2017.07.011

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The value of serum sialic acid levels detection in ovarian cancer

更新时间：2025-12-31

- The value of serum sialic acid levels detection in ovarian cancer
- China Oncology Vol. 27, Issue 7, Pages: 588-592(2017)
- 作者机构：
  
  复旦大学附属肿瘤医院检验科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2017.07.011
  CLC：
- Published Online：16 August 2017，
  
  Published：16 August 2017
- 稿件说明：
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胡宏峰,卢仁泉,胡　娟,等. 卵巢癌患者血清唾液酸含量检测的价值[J]. 中国癌症杂志, 2017, 27(7): 588-592.

胡宏峰, 卢仁泉, 胡　娟. The value of serum sialic acid levels detection in ovarian cancer[J]. China Oncology, 2017, 27(7): 588-592.
胡宏峰,卢仁泉,胡　娟,等. 卵巢癌患者血清唾液酸含量检测的价值[J]. 中国癌症杂志, 2017, 27(7): 588-592. DOI： 10.19401/j.cnki.1007-3639.2017.07.011.

胡宏峰, 卢仁泉, 胡　娟. The value of serum sialic acid levels detection in ovarian cancer[J]. China Oncology, 2017, 27(7): 588-592. DOI： 10.19401/j.cnki.1007-3639.2017.07.011.

摘要

背景与目的：目前临床上用于辅助诊断卵巢癌的血清标志物相对缺乏。该研究旨在探讨血清唾液酸(sialic acid，SA)含量检测在卵巢癌患者的辅助诊断、疗效监测等中的临床应用价值。方法：采用酶法检测332例妇科恶性肿瘤患者、230例妇科良性疾病患者及194名健康对照者的血清SA含量；同时采用化学发光法检测上述标本的血清CA125及HE4含量。结果：妇科恶性肿瘤患者的血清SA含量为584.0(499.8，702.5) mg/L，明显高于妇科良性疾病组［497.0(454.0，559.0) mg/L］及健康对照组［475.0(443.8，505.0)mg/L，P0.05］；其中卵巢癌组血清SA含量最高［675.0(582.0，816.0) mg/L］；血清SA联合CA125检测对卵巢恶性肿瘤的灵敏度高达95.17%，阴性预测值为94.37%；卵巢癌患者随访测定过程中，血清SA含量随着病情的好转，其浓度逐步降低。结论：血清SA含量检测可应用于卵巢癌的早期筛查、鉴别诊断及疗效监测。

Abstract

Background and purpose: There is a lack of serum markers for the diagnosis of ovarian cancer currently. This study aimed to investigate the clinical significance of serum sialic acid (SA) levels in patients with ovarian cancer in auxiliary diagnosis and efficacy monitoring. Methods: Enzyme reaction method was used to analyze serum SA levels and chemiluminescence was employed to detect CA125 and HE4 in participants including 194 healthy controls

332 patients with gynecological cancer and 230 patients with benign disease. Results: The serum SA levels in patients with gynecological cancer ［584.0 (499.8

702.5) mg/L］ were higher than those in patients with benign disease ［497.0 (454.0

559.0) mg/L］ and healthy controls ［475.0 (443.8

505.0) mg/L

P0.05］. The serum SA levels in patients with ovarian malignant tumors ［675.0 (582.0

816.0) mg/L］ were the highest. The sensitivity of the combined detection of serum SA with CA125 for ovarian malignant tumors was up to 95.17%

and the negative predictive value was 94.37%. With the improvement of the condition

the serum concentration of SA in patients with ovarian cancer gradually decreased. Conclusion: The detection of serum SA can be applied to early screening

differential diagnosis and efficacy monitoring.

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