Research progress of long non-coding RNA related to breast cancer

刘　磊; 吴　炅

doi:10.19401/j.cnki.1007-3639.2017.08.011

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Research progress of long non-coding RNA related to breast cancer

更新时间：2025-12-31

- Research progress of long non-coding RNA related to breast cancer
- China Oncology Vol. 27, Issue 8, Pages: 668-674(2017)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院乳腺外科，复旦大学上海医学院肿瘤学系,上海,200032
  2. 南昌大学第二附属医院乳腺外科,江西,南昌,330006
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2017.08.011
  CLC：
- Published Online：21 September 2017，
  
  Published：21 September 2017
- 稿件说明：
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刘　磊,吴　炅. 乳腺癌相关长链非编码RNA的研究进展[J]. 中国癌症杂志, 2017, 27(8): 668-674.

刘　磊, 吴　炅. Research progress of long non-coding RNA related to breast cancer[J]. China Oncology, 2017, 27(8): 668-674.
刘　磊,吴　炅. 乳腺癌相关长链非编码RNA的研究进展[J]. 中国癌症杂志, 2017, 27(8): 668-674. DOI： 10.19401/j.cnki.1007-3639.2017.08.011.

刘　磊, 吴　炅. Research progress of long non-coding RNA related to breast cancer[J]. China Oncology, 2017, 27(8): 668-674. DOI： 10.19401/j.cnki.1007-3639.2017.08.011.

摘要

长链非编码RNA(long non-coding RNA，lncRNA)是一类长度大于200 nt、不能编码蛋白质的RNA，参与基因调控的各个层面。近年来研究发现，多种lncRNA在乳腺癌的发生、发展过程中起着重要的调控作用。该研究就lncRNA在乳腺癌中的异常表达，与乳腺癌的增殖、凋亡、侵袭、转移的关系，以及在乳腺癌早期诊断、药物耐药、判断预后中的作用等相关进展做一综述，希望为乳腺癌的预测、诊断和个体化治疗提供新的靶点和思路。

Abstract

Long non-coding RNA (lncRNA) is a group of functional RNA molecules

which is more than 200 nucleotides in length

lacks ability of encoding protein and participates in all aspects of gene regulation. The current studies have indicated that some lncRNAs take part in regulating the process of breast cancer tumorigenesis and progression. This article reviewed the abnormal expression of lncRNA in breast cancer

its relationship to breast cancer growth

apoptosis

invasion and metastasis

and its function in early diagnosis

drug resistance and prognosis of breast cancer. This review was expected to offer an insight into a new target for the prediction

diagnosis and individual treatment of breast cancer.

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Related Institution

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