Detection of HPV in peripheral blood and its clinical significance

段雅晨; 陈小军; 吴小华

doi:10.19401/j.cnki.1007-3639.2017.11.012

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Detection of HPV in peripheral blood and its clinical significance

更新时间：2025-12-31

- Detection of HPV in peripheral blood and its clinical significance
- China Oncology Vol. 27, Issue 11, Pages: 908-912(2017)
- 作者机构：
  
  复旦大学附属肿瘤医院妇瘤科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2017.11.012
  CLC：
- Published Online：12 December 2017，
  
  Published：12 December 2017
- 稿件说明：
移动端阅览
段雅晨,陈小军,吴小华. HPV的外周循环血测定及临床意义[J]. 中国癌症杂志, 2017, 27(11): 908-912.

段雅晨, 陈小军, 吴小华. Detection of HPV in peripheral blood and its clinical significance[J]. China Oncology, 2017, 27(11): 908-912.
段雅晨,陈小军,吴小华. HPV的外周循环血测定及临床意义[J]. 中国癌症杂志, 2017, 27(11): 908-912. DOI： 10.19401/j.cnki.1007-3639.2017.11.012.

段雅晨, 陈小军, 吴小华. Detection of HPV in peripheral blood and its clinical significance[J]. China Oncology, 2017, 27(11): 908-912. DOI： 10.19401/j.cnki.1007-3639.2017.11.012.

摘要

高危人乳头状瘤病毒(human papillomavirus，HPV)的持续性感染是宫颈癌重要的致病因素，随着近年来宫颈癌HPV疫苗投入市场，关于HPV的检测及临床意义也成为研究热点。因为HPV致癌的特殊性，我们分析了HPV血液检测及临床应用方面存在的困难，并以血液中HPV的检出为理论基础，论证了其重要的临床意义，包括患者预后及治疗的相关最新研究进展。已有研究证实，宫颈癌患者外周循环血中HPV的持续性检出与患者的不良预后密切相关。在此基础之上，针对HPV的靶向治疗及免疫治疗在宫颈癌患者中显现出越发重要的地位。针对我们需要解决的问题，本文将着重阐述目前HPV病毒的血液学检测现状，并对其提出精准检测及治疗预后方面的展望。

Abstract

High risk human papillomavirus (HPV) has been considered as the most pathogenic factor in cervical cancer patients. Since the HPV vaccine was launched on the market

the detection of HPV and its clinical significance have become hot topics. We analysed the difficulties in peripheral blood detection of HPV and clinical practice

and demonstrated the significance including the latest research progress on prognosis and treatment. It has been verified that the persistent detection of HPV in peripheral blood is in accordance with poor prognosis. On this basis

the targeted therapy and immunotherapy for HPV appear more important in treatment. Focusing on the problem we want to solve

this review presented the current state of blood detection. In the end

we gave our perspective on the precise examination means and clinical application.

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