Intensity-modulated radiation therapy (IMRT) considered as the sophisticated treatment technique is widely used to deliver the desired dose to the tumor volume while limiting the dose to the adjacent healthy tissue. The conflict between increasing the target coverage and sparing of organs at risk (OARs) can be partially balanced when many rounds of IMRT optimization are performed. However

this optimization procedure is a trial-and-error process that is greatly dependent on the experience of the treatment planner and the amount of time they spend. Consequently

a prediction of the clinically acceptable plan before the long optimization

would be an effective and efficient way to improve the quality and consistency of treatment plans. This study summarized the up-to-date studies on the automatic planning technique.