Prediction of lymph node metastasis of cervical cancer based on multi-sequence MRI and multi-system imaging omics model

董诗洁; 胡晓欣; 王　葳; 杨　孟; 岳　磊; 童　彤; 顾雅佳

doi:10.19401/j.cnki.1007-3639.2021.06.004

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Prediction of lymph node metastasis of cervical cancer based on multi-sequence MRI and multi-system imaging omics model

更新时间：2025-12-31

- Prediction of lymph node metastasis of cervical cancer based on multi-sequence MRI and multi-system imaging omics model
- China Oncology Vol. 31, Issue 6, Pages: 460-467(2021)
- 作者机构：
  
  复旦大学附属肿瘤医院放射诊断科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2021.06.004
  CLC：
- Published Online：09 July 2021，
  
  Published：09 July 2021
- 稿件说明：
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董诗洁, 胡晓欣, 王　葳, 杨　孟, 岳　磊, 童　彤, 顾雅佳. 基于多序列MRI与多体系影像组学模型预测子宫颈癌淋巴结转移的研究[J]. 中国癌症杂志, 2021, 31(6): 460-467.

董诗洁, 胡晓欣, 王　葳, et al. Prediction of lymph node metastasis of cervical cancer based on multi-sequence MRI and multi-system imaging omics model[J]. China Oncology, 2021, 31(6): 460-467.
董诗洁, 胡晓欣, 王　葳, 杨　孟, 岳　磊, 童　彤, 顾雅佳. 基于多序列MRI与多体系影像组学模型预测子宫颈癌淋巴结转移的研究[J]. 中国癌症杂志, 2021, 31(6): 460-467. DOI： 10.19401/j.cnki.1007-3639.2021.06.004.

董诗洁, 胡晓欣, 王　葳, et al. Prediction of lymph node metastasis of cervical cancer based on multi-sequence MRI and multi-system imaging omics model[J]. China Oncology, 2021, 31(6): 460-467. DOI： 10.19401/j.cnki.1007-3639.2021.06.004.

摘要

Abstract

Background and purpose: It is of great clinical value to search for early biomarkers that can be used to accurately evaluate lymph node metastasis before surgery. This study aimed to investigate the value of magnetic resonance imaging (MRI) omics parameters in predicting cervical cancer lymph node metastasis

and to establish and verify an imaging omics model for preoperative prediction of cervical cancer lymph node metastasis. Methods: The clinical data of 202 patients with non lymph node metastasis and lymph node metastasis of cervical cancer confirmed by postoperative pathological examination in Fudan University Shanghai Cancer Center from June 2015 to September 2019 were retrospectively analyzed. MRI images were selected as T2 weighted images (T2WI) and T1 contrast + (T1C+). Itk-snap software was used for three-dimensional manual segmentation of cervical cancer tumor regions. Through Pyradiomics

an open source Python package

and a Python programming platform Jupyter

imaging omics features were extracted through ten image type systems and 6 feature systems. Among a total of 202 patients with cervical cancer

104 had no lymph node metastasis

and 98 had lymph node metastasis. Imaging features were extracted from each patient in each group

including 1 923 features from the lymph node metastasis group and no lymph node metastasis group of T2WI sequence

1 923 features from the lymph node metastasis group and no lymph node metastasis group of T1C+ sequence

and 3 846 features from the lymph node metastasis group and no lymph node metastasis group of T2WI combined with T2WI-T1C+ sequence. Imaging omics label was established and validated by machine learning model. Finally

area under curve (AUC)

accuracy

positive predictive value (PPV) and negative predictive value (NPV) of the training set and the test set were used as the quantitative performance of the imaging omics label. Results: The T2WI sequence selected the features in the first 14 for classifier training

with the AUC of the training set=0.810 and the AUC of the test set =0.773. For T1C+ sequence

the first 16 features of feature sequencing were selected for classifier training

with AUC=0.819 in the training set and AUC=0.781 in the test set. In T2WI combined with T1C+sequence

the first 16 features of feature sequencing were selected for classifier training

with AUC=0.841 in the training set and AUC=0.803 in the test set. Conclusion: T2WI combined with T1C+ sequential imaging omics model has a good efficacy in predicting lymph node metastasis of early cervical cancer.

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