马祎菲, 梁新军, 魏少忠. Prognostic value of inflammatory and immune markers in resectable colorectal cancer[J]. China Oncology, 2021, 31(9): 845-851. DOI: 10.19401/j.cnki.1007-3639.2021.09.011.
Prognostic value of inflammatory and immune markers in resectable colorectal cancer
Colorectal cancer is one of the most common malignant tumors in the world. The incidence and mortality of colorectal cancer are increasing year by year in China
and the trend of younger age is becoming more and more obvious. Immune and inflammation-mediated anti-tumor responses are particularly important in the process of tumor treatment
and play an important role in the multi-stage development of tumors. In recent years
researchers have found that neutrophil-lymphocyte ratio (NLR)
platelet- lymphocyte ratio (PLR) and prognostic nutritional index (PNI)
which are systemic inflammatory markers
can guide the prognosis of patients undergoing radical colorectal cancer surgery. In addition
tumor-infiltrating lymphocytes (TIL) and tumor-associated macrophages (TAM) have also become a focus of research. As early as 2005
scholars found that for patients with colorectal cancer undergoing radical resection
the infiltrating lymphocytes in the tumor tissues were related to the prognosis of these patients
and the higher the density of infiltrating lymphocytes
the better the prognosis of the patients. In recent years
more and more studies have been conducted to verify these conclusions and explore the underlying mechanism. Traditional TNM staging system has been widely used to predict the prognosis of patients with colorectal cancer
however
it represents the biological behavior of the tumor and cannot accurately predict the risk of death and recurrence of patients with colorectal cancer. Some studies have established an individualized prediction model and visualized the prediction model by using the nomogram to predict the prognosis of resectable colorectal cancer patient with higher efficiency. This paper aimed to explore the predictive status of inflammatory markers and immune markers in resectable colorectal cancer
and at the same time
to search for a more efficient prognosis model of colorectal cancer to predict the prognosis of patient with resectable colorectal cancer more accurately.
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Related Author
Jun LI
Tingwei LU
Xuqian FANG
Wen WU
Ruoxin ZHANG
Junyong WENG
Yanlei MA
Guoxiang CAI
Related Institution
Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University
Department of Colorectal Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University
Department of Oncology, Huadong Hospital Affiliated to Fudan University