Expression difference and clinical significance of CHKα in different grades of gliomas

黄　灵; 邹有瑞; 马　悦; 李琢琦; 高鑫义; 阿布拉古; 马　辉

doi:10.19401/j.cnki.1007-3639.2021.10.003

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Expression difference and clinical significance of CHKα in different grades of gliomas

更新时间：2025-12-31

- Expression difference and clinical significance of CHKα in different grades of gliomas
- China Oncology Vol. 31, Issue 10, Pages: 892-898(2021)
- 作者机构：
  
  1. 宁夏医科大学临床医学院,宁夏,银川,750004
  2. 宁夏医科大学总医院神经外科,宁夏,银川,750004
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2021.10.003
  CLC：
- Published Online：08 November 2021，
  
  Published：08 November 2021
- 稿件说明：
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黄　灵, 邹有瑞, 马　悦, 李琢琦, 高鑫义, 阿布拉古, 马　辉 . 胆碱激酶α在不同级别胶质瘤中的表达差异及临床意义[J]. 中国癌症杂志, 2021, 31(10): 892-898.

黄　灵, 邹有瑞, 马　悦, et al. Expression difference and clinical significance of CHKα in different grades of gliomas[J]. China Oncology, 2021, 31(10): 892-898.
黄　灵, 邹有瑞, 马　悦, 李琢琦, 高鑫义, 阿布拉古, 马　辉 . 胆碱激酶α在不同级别胶质瘤中的表达差异及临床意义[J]. 中国癌症杂志, 2021, 31(10): 892-898. DOI： 10.19401/j.cnki.1007-3639.2021.10.003.

黄　灵, 邹有瑞, 马　悦, et al. Expression difference and clinical significance of CHKα in different grades of gliomas[J]. China Oncology, 2021, 31(10): 892-898. DOI： 10.19401/j.cnki.1007-3639.2021.10.003.

摘要

背景与目的：胶质瘤是颅内中枢神经系统最常见的恶性肿瘤，常规治疗效果往往不理想。胆碱激酶α（choline kinase alpha，CHKα）与肿瘤的发生、发展密切相关。探讨CHKα在胶质瘤中的表达及与患者预后的关系。方法：回顾并分析宁夏医科大学总医院神经外科2017年1月—2019年12月收治的120例胶质瘤患者的临床病理学资料。患者根据世界卫生组织（World Health Organization，WHO）分级标准分为Ⅰ~Ⅳ级。采用免疫组织化学染色法检测CHKα在不同级别胶质瘤中的表达，分析CHKα的表达与患者的临床病理学特征之间的关系。采用Kaplan-Meier法对患者的生存情况进行分析。采用生物信息学数据库中的相关临床数据对CHKα表达与脑胶质瘤患者的生存关系进行进一步验证。结果：脑胶质瘤患者120例中，男性62例，女性58例。病理学类型包括毛细胞型星形细胞瘤32例，弥漫性星形细胞瘤26例，间变型星形细胞瘤30例，多形性胶质母细胞瘤32例。CHKα表达阳性率分别为9.77%、7.81%、95.03%和92.90%。CHKα蛋白在不同级别的胶质瘤组织中表达差异有统计学意义（P＜0.01）。截至2021年6月30日，有60例患者死亡，10例失访，随访率为91.67%。采用Kaplan-Meier法分析CHKα蛋白在不同级别胶质瘤中的表达差异与患者预后的关系，结果发现，CHKα低表达患者的总生存期比高表达者长，预后佳，并发症发生率显著低于CHKα高表达组，差异有统计学意义（P＜0.01）。这一结果与生物信息学分析结果相符（P＜0.05）。结论：CHKα在不同级别胶质瘤中的表达差异显著，且与患者预后密切相关。CHKα的表达情况可作为胶质瘤患者的诊断和判断患者预后的指标。

Abstract

Background and purpose: Glioma is one of the most common intracranial malignant tumors with a poor prognosis. Choline kinase alpha (CHKα) is closely associated with the occurrence and development of gliomas. This study aimed to analyze the CHKα protein expression in glioma tissues and its relationship with prognosis. Methods: A total of 120 glioma patients treated in Department of Neurosurgery

Ningxia Medical University General Hospital from 2017 to 2019 were enrolled in this study. All patients were categorized by World Health Organization (WHO) grading Ⅰ-Ⅳ. Immunohistochemistry was used to detect the expression of CHKα. The relationship between the expression of CHKα and the clinicopathological features of patients was analyzed. Kaplan-Meier method was used to analyze the survival of patients. The relationship between CHKα and the survival of patients with glioma was further verified by using the relevant clinical data in the bioinformatics database. Results: Among the 120 glioma patients

62 were male

and 58 were females. The pathological types included 32 pilocytic astrocytoma

26 diffuse astrocytoma

30 anaplastic astrocytoma and 32 glioblastoma multiforme. The positive expression rates of CHKα were 9.77%

7.81%

95.03% and 92.90%

respectively (P ＜ 0.01). Sixty patients died by June 30

2021

and 10 patients were lost during follow-up. The follow-up rate was 91.67%. Kaplan-Meier method analysis showed that the overall survival time of patients with low CHKα expression was longer

the prognosis was better

and the side effect occurrence rate was lower

compared with patients with high CHKα expression (P ＜ 0.01). These results were consistent with the results of bioinformatics analysis (P ＜ 0.05). Conclusion: CHKα is differentially expressed in glioma tissues of different grades

and is correlated with poor prognosis in glioma patients. CHKα is a potential indicator of the prognosis in glioma patients.

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