Single-cell RNA sequencing and its application in breast cancer

韩香臣; 李小光; 胡　欣

doi:10.19401/j.cnki.1007-3639.2021.11.010

您当前的位置：

首页 >

文章列表页 >

Single-cell RNA sequencing and its application in breast cancer

更新时间：2025-12-31

- Single-cell RNA sequencing and its application in breast cancer
- China Oncology Vol. 31, Issue 11, Pages: 1110-1114(2021)
- 作者机构：
  
  复旦大学附属肿瘤医院乳腺外科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2021.11.010
  CLC：
- Published Online：03 December 2021，
  
  Published：03 December 2021
- 稿件说明：
移动端阅览
韩香臣, 李小光, 胡　欣. 单细胞转录组测序及其在乳腺癌中的应用[J]. 中国癌症杂志, 2021, 31(11): 1110-1114.

韩香臣, 李小光, 胡　欣. Single-cell RNA sequencing and its application in breast cancer[J]. China Oncology, 2021, 31(11): 1110-1114.
韩香臣, 李小光, 胡　欣. 单细胞转录组测序及其在乳腺癌中的应用[J]. 中国癌症杂志, 2021, 31(11): 1110-1114. DOI： 10.19401/j.cnki.1007-3639.2021.11.010.

韩香臣, 李小光, 胡　欣. Single-cell RNA sequencing and its application in breast cancer[J]. China Oncology, 2021, 31(11): 1110-1114. DOI： 10.19401/j.cnki.1007-3639.2021.11.010.

摘要

乳腺癌占全部女性癌症的17.1%，位于中国女性癌症发病率首位。尽管目前根据乳腺癌分子分型采用的个体化治疗策略使乳腺癌治疗取得了阶段性突破，但是肿瘤异质性、耐药、转移等问题依然阻碍我们进一步提升临床疗效。单细胞转录组测序是一项能在单细胞水平上进行无偏倚、高通量、高分辨率全转录组学分析的新技术。该技术能以单细胞分辨率分析肿瘤内部基因表达特征，对认识乳腺癌具有不可替代的作用。就单细胞测序技术在肿瘤异质性、肿瘤微环境、转移、耐药等方面的应用进行综述，以期更加深刻地了解该技术并为乳腺癌研究提供全新思路。

Abstract

Breast cancer

accounting for 17.1% of the female cancers

is the most frequently diagnosed malignancy among women in China. Current treatment strategies based on the breast cancer subtype have remarkably improved the prognosis

however

obstacles remain. It’s of great importance to elucidate problems

including the tumor heterogeneity

metastases and therapeutic resistance

to promote therapeutic efficacy. Single-cell RNA sequencing is a novel method that enables unbiased

high-throughput and high-resolution transcriptomic analysis at the single-cell level. It could profile intratumor gene expression features at single-cell resolution and improve our understanding of breast cancer. This review illustrated the application of single-cell RNA sequencing in breast cancer from diverse aspects to obtain further knowledge of this emerging technology and provided new insights into breast cancer research.

关键词

Keywords

references

Views

1814

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The value of single-cell sequencing in oral squamous cell carcinoma research

Receptor discordance between primary breast cancer and liver metastases

Application progress of single-cell sequencing technology in breast cancer research

Research progress and clinical significance of breast cancer heterogeneity

Scheduling of chemotherapy based on direct monitoring of pO2 in tumor microenvironment by EPR oximetry

Related Author

Xiaocong WANG

Ming LI

Yizi JIN

Mingxi LIN

Jian ZHANG

Qiang LIU

Yi FANG

Jing WANG

Related Institution

School of Stomatology, Hunan University of Chinese Medicine

Changsha Stemmatological Hospital Special Clinic Center

Phase Ⅰ Clinical Trial Center, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

南京医科大学附属上海一院临床医学院肿瘤科

AI问答

⁰