Meta-analysis of the association between gene alterations and distant metastasis of differentiated thyroid carcinoma in children and adolescents

Shuting DENG; Yuan FENG; Kai QIAN; Kai GUO; Zhuoying WANG

doi:10.19401/j.cnki.1007-3639.2022.05.003

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Meta-analysis of the association between gene alterations and distant metastasis of differentiated thyroid carcinoma in children and adolescents

Specialists' Article | 更新时间：2025-12-31

- Meta-analysis of the association between gene alterations and distant metastasis of differentiated thyroid carcinoma in children and adolescents
- China Oncology Vol. 32, Issue 5, Pages: 388-396(2022)
- 作者机构：
  
  上海交通大学医学院附属仁济医院头颈外科,上海 200001
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2022.05.003
  CLC： R736.1
- Received：25 March 2022，
  
  Revised：2022-05-01，
  
  Published：30 May 2022
- 稿件说明：
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Shuting DENG, Yuan FENG, Kai QIAN, et al. Meta-analysis of the association between gene alterations and distant metastasis of differentiated thyroid carcinoma in children and adolescents[J]. China Oncology, 2022, 32(5): 388-396.
DOI：

Shuting DENG, Yuan FENG, Kai QIAN, et al. Meta-analysis of the association between gene alterations and distant metastasis of differentiated thyroid carcinoma in children and adolescents[J]. China Oncology, 2022, 32(5): 388-396. DOI： 10.19401/j.cnki.1007-3639.2022.05.003.

摘要

背景与目的：

甲状腺癌是世界范围内增长率较高的恶性肿瘤之一

在儿童及青少年中甲状腺癌的发病率也在逐年增加。本研究旨在对基因突变特征与儿童及青少年分化型甲状腺癌（differentiated thyroid carcinoma

DTC）远处转移的相关性进行meta分析。

方法：

数据库搜索探究基因突变特征与儿童及青少年DTC远处转移相关性的研究

运用STATA 14.0软件分析与远处转移相关的基因突变特征。

结果：

纳入20项研究

共涉及1 273例患者

分析结果显示

BRAF

V600E突变阴性、

RET

基因融合阳性是儿童及青少年DTC远处转移的危险因素

而

NTRK

基因融合与远处转移未见明显相关性。

结论：

本研究发现了与儿童及青少年DTC远处转移相关的几个基因突变特征

有利于患者预后的评估及治疗方案的制定。

Abstract

Background and purpose:

Thyroid cancer is one of the fastest increasing malignan

cies worldwide

and its incidence in children and adolescents has also been increasing over the years. Meta-analysis were performed to investigate the correlation between gene alteration patterns and distant metastasis of differentiated thyroid carcinoma (DTC) in children and adolescents.

Methods:

Databases were used to search studies on the association between gene alteration patterns and distant metastasis of DTC in children and adolescents

and STATA 14.0 software was used to analyze the gene alterations related to distant metastasis.

Results:

Twenty studies involving 1 273 patients were included

and the analysis showed that negative BRAF V600E mutation and positive RET gene fusion were risk factors for distant metastasis in DTC in children and adolescents

while NTRK gene fusion was not significantly associated with distant metastasis.

Conclusion:

Our research identified several genetic alterations associated with distant metastasis in DTC in children and adolescents

which could be guidance for prognosis assessment and treatment planning.

关键词

Keywords

references

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