Clinical research progress in the treatment of <italic style="font-style: italic">BRAF</italic> V600 mutation-positive advanced melanoma

Jianyun JIANG; Hongmei YING

doi:10.19401/j.cnki.1007-3639.2022.05.010

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Clinical research progress in the treatment of BRAF V600 mutation-positive advanced melanoma

Review | 更新时间：2025-12-31

- Clinical research progress in the treatment of BRAF V600 mutation-positive advanced melanoma
- China Oncology Vol. 32, Issue 5, Pages: 445-450(2022)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院放射治疗中心,复旦大学上海医学院肿瘤学系,上海 200032
  2. 上海市放射肿瘤学重点实验室,上海 200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2022.05.010
  CLC： R739.5
- Received：29 January 2022，
  
  Revised：2022-05-11，
  
  Published：30 May 2022
- 稿件说明：
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Jianyun JIANG, Hongmei YING. Clinical research progress in the treatment of BRAF V600 mutation-positive advanced melanoma[J]. China Oncology, 2022, 32(5): 445-450.
DOI：

Jianyun JIANG, Hongmei YING. Clinical research progress in the treatment of BRAF V600 mutation-positive advanced melanoma[J]. China Oncology, 2022, 32(5): 445-450. DOI： 10.19401/j.cnki.1007-3639.2022.05.010.

摘要

多数黑色素瘤具有

BRAF

V600E/K突变

因此V600成为黑色素瘤精准治疗的重要靶点

并通常可被BRAF抑制剂和MEK抑制剂联合阻断。免疫检查点抑制剂的出现也极大地改善了

BRAF

V600突变阳性的晚期黑色素瘤患者的治疗结局

探究这部分患者的最佳一线治疗及序贯治疗顺序的临床试验正在开展。本文就精准医疗时代

BRAF

V600突变阳性的晚期黑色素瘤患者治疗的最新研究进展进行综述。

Abstract

Most melanomas have

BRAF

V600E/K mutations

making V600 an important target for precision treatment of melanoma

and it can often be blocked by a combination of BRAF inhibitors and MEK inhibitors. The emergence of immune checkpoint inhibitors has also greatly improved the treatment outcome of patients with

BRAF

V600 mutation-positive advanced melanoma. Clinical trials are also underway to determine the best first-line treatment and the sequence of combination therapies for these patients. This paper reviewed the latest progress in the treatment of

BRAF

V600 mutation-positive advanced melanoma in the era of precision medicine.

关键词

Keywords

references

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Clinical research progress in the treatment of BRAF V600 mutation-positive advanced melanoma

DOI：10.19401/j.cnki.1007-3639.2022.05.010

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