New research advances and future prospect in precision treatment of triple-negative breast cancer

Yuling XIAO; Xiuzhi ZHU; Yizhou JIANG; Zhimin SHAO

doi:10.19401/j.cnki.1007-3639.2022.08.001

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New research advances and future prospect in precision treatment of triple-negative breast cancer

Specialists' Commentary | 更新时间：2025-12-31

- New research advances and future prospect in precision treatment of triple-negative breast cancer
- China Oncology Vol. 32, Issue 8, Pages: 669-679(2022)
- 作者机构：
  
  复旦大学附属肿瘤医院乳腺外科/复旦大学乳腺癌研究所,复旦大学上海医学院肿瘤学系,上海 200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2022.08.001
  CLC： R737.9
- Received：20 June 2022，
  
  Revised：2022-07-10，
  
  Published：30 August 2022
- 稿件说明：
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Yuling XIAO, Xiuzhi ZHU, Yizhou JIANG, et al. New research advances and future prospect in precision treatment of triple-negative breast cancer[J]. China Oncology, 2022, 32(8): 669-679.
DOI：

Yuling XIAO, Xiuzhi ZHU, Yizhou JIANG, et al. New research advances and future prospect in precision treatment of triple-negative breast cancer[J]. China Oncology, 2022, 32(8): 669-679. DOI： 10.19401/j.cnki.1007-3639.2022.08.001.

摘要

世界卫生组织国际癌症研究机构最新发布的数据显示

乳腺癌现已取代肺癌成为全球发病率最高的恶性肿瘤。三阴性乳腺癌（triple-negative breast cancer

TNBC）是雌激素受体（estrogen receptor

ER）、孕激素受体（progesterone receptor

PR）和人表皮生长因子受体2（human epidermal growth factor receptor 2

HER2）表达均为阴性的乳腺癌

与其他分子分型的乳腺癌相比

TNBC具有易复发转移、整体预后差等特点。TNBC对内分泌治疗及抗HER2治疗不敏感

化疗是其主要的系统治疗手段。随着基因组学、转录组学、代谢组学、蛋白组学、微生物组学的蓬勃发展及对TNBC分子分型的深入研究

针对不同靶点的靶向治疗药物和针对免疫检查点的免疫治疗药物的出现

如多聚腺苷二磷酸核糖聚合酶[poly(ADP-ribose) polymerase

PARP]抑制剂、人滋养细胞表面抗原2（trophoblast cell-surface antigen 2

TROP-2）抗体药物偶联物、pembrolizumab、atezolizumab、durvalumab等

已为TNBC的治疗提供新的手段

正在改变TNBC的临床实践。“精准治疗”“分类而治”是未来发展的方向。本文以TNBC的分子分型为基础

对其靶向治疗和免疫治疗研究的新进展进行归纳总结

以期为今后TNBC精准治疗策略提供参考。

Abstract

According to the latest data released by the Cancer Research Institute of the World Health Organization

breast cancer has replaced lung cancer as the malignant tumor with the highest incidence rate in the world. Triple-negative breast cancer (TNBC) is defined by a lack of estrogen receptor (ER)

progesterone receptor (PR)

and human epidermal growth factor receptor 2 (HER2). Compared with other types of breast cancer

TNBC bears the characteristics of high metastasis rate

strong invasiveness and poor prognosis. TNBC is not sensitive to endocrine therapy and anti-HER2 therapy

and chemotherapy is its main systemic treatment. With the vigorous development of genomics

transcriptomics

metabolomics

proteomics

microbiomics technologies and the in-depth study of TNBC molecular subtyping

targeted therapy and immunotherapy drugs

including poly(ADP-ribose) polymerase (PARP) inhibitors

trophoblast cell-surface antigen 2 (TROP-2) antibody-drug conjugate

pembrolizumab

atezolizumab

durvalumab

etc.

have provided new therapeutic methods

which are changing the clinical practice and treatment pattern of TNBC. It is believed accurate therapy will become a new direction of development in the future. Based on the molecular subtypes of TNBC

here we summarized the research advances in targeted therapy and immunotherapy of TNBC

in order to provide reference for the precise treatment strategy of TNBC in the future.

关键词

Keywords

references

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