Advances of liquid biopsy in precision treatment of breast cancer

Yu ZHANG; Qiang LIU

doi:10.19401/j.cnki.1007-3639.2022.08.003

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Advances of liquid biopsy in precision treatment of breast cancer

Specialists' Commentary | 更新时间：2025-12-31

- Advances of liquid biopsy in precision treatment of breast cancer
- China Oncology Vol. 32, Issue 8, Pages: 688-697(2022)
- 作者机构：
  
  中山大学孙逸仙纪念医院乳腺肿瘤中心,广东广州 510000
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2022.08.003
  CLC： R737.9
- Received：01 July 2022，
  
  Revised：2022-07-20，
  
  Published：30 August 2022
- 稿件说明：
移动端阅览
Yu ZHANG, Qiang LIU. Advances of liquid biopsy in precision treatment of breast cancer[J]. China Oncology, 2022, 32(8): 688-697.
DOI：

Yu ZHANG, Qiang LIU. Advances of liquid biopsy in precision treatment of breast cancer[J]. China Oncology, 2022, 32(8): 688-697. DOI： 10.19401/j.cnki.1007-3639.2022.08.003.

摘要

在全球范围内

乳腺癌是女性最常见的恶性肿瘤。近年来

迅速扩大的基因组学知识体系不仅揭示了恶性肿瘤的复杂性

也使得恶性肿瘤的治疗范式从以肿瘤类型为导向逐渐转向以基因为导向

根据生物标志物分析为患者进行个体化治疗。目前大量研究已证实从患者获得肿瘤分子图谱优化了癌症个性化治疗方案的选择

以及对治疗反应、耐药及肿瘤复发的监测。而液体活检

通过对体液中肿瘤衍生材料所包含的基因组等数据进行分析

可以获得关于个体患者肿瘤特征的详细信息

为基于精准医学的治疗开辟新思路。在乳腺癌精准治疗中

液体活检可以预测生存预后、检测微小残留疾病（minimal residual disease

MRD）、监测治疗效果

在（新）辅助治疗及解救治疗中发挥作用。虽然液体活检在乳腺癌精准治疗方面的研究取得了令人瞩目的进展

但是仍存在一些问题

还需要更多的工作来进一步改进技术。本文将就近年来液体活检在乳腺癌精准治疗中的应用研究进展进行综述

并对未来的发展趋势予以展望。

Abstract

Breast cancer is the most common malignant tumor in women worldwide. Recently

the complexity of malignant tumors has been revealed following the rapid expansion of the knowledge system of genomics

and the treatment of tumors has shifted from tumor type-oriented therapy to gene-oriented therapy

which is based on biomarker analysis. Great efforts have proved that tumor molecular profiles from patients are capable to improve the selection of personalized treatment options

as well as monitoring of treatment response

drug resistance and tumor recurrence. Liquid biopsy

a method to analyze the genome and other data contained in tumor-derived materials in body fluids

can obtain detailed information about the characteristics of individual patient's tumors

providing new ideas for precision treatment. In the precise treatment of breast cancer

liquid biopsy can predict survival prognosis

detect minimal residual disease (MRD)

monitor treatment efficacy

and play a role in (neo)adjuvant treatment and rescue treatment. Although the research of liquid biopsy in the precise treatment of breast cancer has made remarkable progress

there are still some problems

and more work is needed to further improve the technology. In this paper

we reviewed the research progress of liquid biopsy in the precision therapy of breast cancer in recent years

and the future trend of liquid biopsy is forecasted.

关键词

Keywords

references

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