Evolution in the surgical treatment concepts of pancreatic neuroendocrine tumors

Xianze WANG; Wenming WU

doi:10.19401/j.cnki.1007-3639.2022.09.002

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Evolution in the surgical treatment concepts of pancreatic neuroendocrine tumors

Specialists' Commentary | 更新时间：2025-12-31

- Evolution in the surgical treatment concepts of pancreatic neuroendocrine tumors
- China Oncology Vol. 32, Issue 9, Pages: 765-771(2022)
- 作者机构：
  
  1. 中国医学科学院北京协和医学院北京协和医院基本外科,北京 100730
  2. 疑难重症及罕见病国家重点实验室,北京 100730
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2022.09.002
  CLC： R735.9
- Received：02 August 2022，
  
  Revised：2022-09-03，
  
  Published：30 September 2022
- 稿件说明：
移动端阅览
Xianze WANG, Wenming WU. Evolution in the surgical treatment concepts of pancreatic neuroendocrine tumors[J]. China Oncology, 2022, 32(9): 765-771.
DOI：

Xianze WANG, Wenming WU. Evolution in the surgical treatment concepts of pancreatic neuroendocrine tumors[J]. China Oncology, 2022, 32(9): 765-771. DOI： 10.19401/j.cnki.1007-3639.2022.09.002.

摘要

胰腺神经内分泌肿瘤（pancreatic neuroendocrine neoplasm

pNEN）是一类具有高度异质性的肿瘤。外科手术是pNEN综合治疗的重要环节

但pNEN较低的发病率和较强的异质性导致其外科领域进展相对缓慢。在治疗理念上

pNEN的外科治疗策略逐渐由病情导向转变为预后导向

对肿瘤特征的评估更加依赖形态学联合分子病理学的方法。此外

pNEN手术治疗正在向个体化、微创化、精细化的方向发展

手术的介入时机也逐步拓展至患者的全诊疗周期。本文将结合国内外相关领域研究进展

分析现阶段pNEN外科治疗面临的问题与挑战

并探讨治疗理念的转变及潜在的突破方向。

Abstract

Pancreatic neuroendocrine neoplasm (pNEN) is highly heterogeneous. Surgery is an important part of the comprehensive treatment for pNEN

however

the low incidence and strong heterogeneity of the disease retard the progress of surgical treatment. In terms of treatment concepts

the therapeutic strategy of surgery may transform from condition-orientated to prognosis-orientated treatment

and the evaluation of tumor characteristics relies more on morphology combined with molecular pathology. In addition

pNEN surgical treatment is becoming individualized

minimally invasive and delicate

and the timing of surgical intervention has extended to the entire disease period. Based on the research progresses in related fields

we analyzed the issues and challenges and discussed the evolution in the surgical treatment concepts of pNEN.

关键词

Keywords

references

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