Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer

Dan SONG; Yaxin CHAI; Yanping GE

doi:10.19401/j.cnki.1007-3639.2025.03.008

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Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer

Article | 更新时间：2025-12-31

- Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer
- China Oncology Vol. 35, Issue 3, Pages: 320-325(2025)
- 作者机构：
  
  新乡市中心医院（新乡医学院第四临床学院）核磁共振科，河南新乡 453000
- 作者简介：
- 基金信息：
  
  Key Projects of Medical Science and Technology in Henan Province Purpose(LHGJ20210902)
- DOI：10.19401/j.cnki.1007-3639.2025.03.008
  CLC： R735.3+7
- Received：12 November 2024，
  
  Revised：2025-02-05，
  
  Published：30 March 2025
- 稿件说明：
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Dan SONG, Yaxin CHAI, Yanping GE. Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer[J]. China Oncology, 2025, 35(3): 320-325.
DOI：

Dan SONG, Yaxin CHAI, Yanping GE. Relationship between quantitative analysis parameters of DCE-MRI and microangiogenesis in rectal cancer[J]. China Oncology, 2025, 35(3): 320-325. DOI： 10.19401/j.cnki.1007-3639.2025.03.008.

摘要

背景与目的：

肿瘤微血管生成是肿瘤生长、转移的重要基础，其特征包括血管新生、血管通透性增加及毛细血管结构异常等。微血管生成不仅影响肿瘤的供血和代谢，还与肿瘤的侵袭性、患者预后及治疗反应直接相关。动态对比增强磁共振成像（dynamic contrast-enhanced magnetic resonance imaging，DCE-MRI）是一种非侵入性的影像学技术，通过定量分析对比剂在肿瘤组织中的分布和动态变化，能够反映肿瘤的微血管密度（microvascular density，MVD）、通透性和血流灌注状态。本研究旨在通过深入分析直肠癌DCE-MRI定量分析参数与微血管生成的关系，进一步明确其在直肠癌诊断和治疗中的应用价值，并推动该技术在临床实践中的普及和优化。

方法：

选取2021年1月—2024年6月新乡市中心医院收治的348例拟行手术治疗的直肠癌患者，并收集直肠癌组织标本和癌旁组织（距离肿瘤边缘

5 cm）。本研究经新乡市中心医院医学伦理委员会审批通过（批号：2021-144-01K）。比较癌组织、癌旁组织中的DCE-MRI定量分析参数[速率常数（rate constant，K

）、容积转运常数（volume transfer constant，K

trans

）、细胞外间隙对比剂容积分数（extravascular extracellular volume fraction，V

）

]

和MVD。对比不同分化程度、临床分期直肠癌患者的DCE-MRI定量分析参数和MVD。采用Spearman相关系数分析直肠癌患者的DCE-MRI参数与分化程度、临床分期及MVD的相关性。

结果：

直肠癌组织的K

值、K

trans

值、V

值及MVD均高于癌旁组织（

0.05）。低分化和中分化直肠癌患者的K

值、K

trans

值、V

值及MVD均高于高分化直肠癌患者（

0.05），低分化直肠癌患者的K

值、K

trans

值、V

值及MVD均高于中分化直肠癌患者（

0.05）。Ⅱ期、Ⅲ期和Ⅳ期直肠癌患者的K

值、K

trans

值、V

值及MVD均高于Ⅰ期直肠癌患者（

0.05），Ⅲ期和Ⅳ期直肠癌患者的K

值、K

trans

值、V

值及MVD均高于Ⅱ期直肠癌患者（

0.05），Ⅳ期直肠癌患者的K

值、K

trans

值、V

值及MVD均高于Ⅲ期直肠癌患者（

0.05）。直肠癌患者的K

值、K

trans

值及V

值与分化程度均呈负相关（

=-0.683、-0.743、-0.721，

0.05），直肠癌患者的K

值、K

trans

值及V

值与临床分期均呈正相关（

=0.764、0.703、0.814，

0.05），直肠癌患者的K

值、K

trans

值及V

值与MVD均呈正相关（

=0.812、0.754、0.835，

0.05）。

结论：

DCE-MRI参数与直肠癌分化程度、临床分期及微血管生成均相关。

Abstract

Background and purpose:

Tumor microangiogenesis is an important basis for tumor growth and metastasis

and its characteristics include angiogenesis

increased vascular permeability and abnormal capillary structure. Microangiogenesis not only affects the blood supply and metabolism of tumor

but also is directly related to the invasion

prognosis and treatment response of tumor. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a non-invasive imaging technique. By quantitatively analyzing the distribution and dynamic changes of contrast agents in tumor tissues

it can reflect the microvascular density (MVD)

permeability and blood perfusion of tumors. The purpose of this study was to further clarify the application value of DCE-MRI in the diagnosis and treatment of rectal cancer by in-depth analysis of the relationship between quantitative analysis parameters of rectal cancer and microangiogenesis

and to promote the popularization and optimization of this technology in clinical pr

actice.

Methods:

A total of 348 patients with rectal cancer who were scheduled for surgical treatment in Xinxiang Central Hospital from January 2021 to June 2024 were selected

and rectal cancer tissue specimens and adjacent tissues (

5 cm away from tumor margin) were collected. This study was approved by the medical ethics committee of Xinxiang Central Hospital (approval number: 2021-144-01K). The quantitative analysis parameters of DCE-MRI [Rate constant (K

)

volume transport constant (K

trans

)

volume fraction of contrast agent in extracellular space (VE)

]

and MVD in cancer tissues and adjacent tissues were compared. The quantitative analysis parameters and MVD of DCE-MRI in rectal cancer patients with different differentiation degrees and clinical stages were compared. Spearman correlation was used to analyze the correlation between DCE-MRI parameters and differentiation degree

clinical stage and MVD in patients with rectal cancer.

Results:

The values of K

value

trans

value

value and MVD were higher in rectal cancer tissues than in adjacent tissues (

0.05). The K

value

trans

value

value and MVD of patients with low differentiated and middle differentiated rectal cancer were higher than those of patients with high differentiated rectal cancer (

0.05). The values of K

value

trans

value

value and MVD of patients with low differentiated rectal cancer were higher than those of patients with middle differentiated rectal cancer (

0.05). The K

value

trans

value

value and MVD of patients with stage Ⅱ

Ⅲ and Ⅳ rectal cancer were higher than those of patients with stage Ⅰ rectal cancer (

0.05). The K

value

trans

value

value and MVD of patients with stage Ⅲ and Ⅳ rectal cancer were hi

gher than those of patients with stage Ⅱ rectal cancer (

0.05). The K

value

trans

value

value and MVD of patients with stage Ⅳ rectal cancer were higher than those of patients with stage Ⅲ rectal cancer (

0.05). The K

value

trans

value and V

value of rectal cancer patients were negatively correlated with the differentiation degree (

=-0.683

-0.743

-0.721

0.05). The K

value

trans

value and V

value of rectal cancer patients were positively correlated with clinical stage (

=0.764

0.703

0.814

0.05). The K

value

trans

value and V

value of rectal cancer patients were positively correlated with MVD (

=0.812

0.754

0.835

0.05).

Conclusion:

DCE-MRI parameters are related to the differentiation degree

clinical stage and microangiogenesis of rectal cancer.

关键词

Keywords

references

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