Interpretation of the 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer: perioperative assessment and management of parathyroid function and precision individualized management of postoperative TSH suppression in adults with differentiated thyroid cancer

Yiming WU; Chuyao FENG; Ying GAO; Xiaohong WU

doi:10.19401/j.cnki.1007-3639.2025.09.004

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Interpretation of the 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer: perioperative assessment and management of parathyroid function and precision individualized management of postoperative TSH suppression in adults with differentiated thyroid cancer

Specialist's Commentary | 更新时间：2025-12-31

- Interpretation of the 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer: perioperative assessment and management of parathyroid function and precision individualized management of postoperative TSH suppression in adults with differentiated thyroid cancer
- China Oncology Vol. 35, Issue 9, Pages: 841-849(2025)
- 作者机构：
  
  1. 北京大学第一医院内分泌科，北京 100034
  2. 浙江省人民医院内分泌科，浙江杭州 310014
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2025.09.004
  CLC： R736.1
- Received：10 September 2025，
  
  Revised：2025-09-23，
  
  Published：30 September 2025
- 稿件说明：
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Yiming WU, Chuyao FENG, Ying GAO, et al. Interpretation of the 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer: perioperative assessment and management of parathyroid function and precision individualized management of postoperative TSH suppression in adults with differentiated thyroid cancer[J]. China Oncology, 2025, 35(9): 841-849.
DOI：

Yiming WU, Chuyao FENG, Ying GAO, et al. Interpretation of the 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer: perioperative assessment and management of parathyroid function and precision individualized management of postoperative TSH suppression in adults with differentiated thyroid cancer[J]. China Oncology, 2025, 35(9): 841-849. DOI： 10.19401/j.cnki.1007-3639.2025.09.004.

摘要

近年来，分化型甲状腺癌（differentiated thyroid cancer，DTC）的发病率持续上升，其围手术期管理和术后促甲状腺激素（thyroid-stimulating hormone，TSH）抑制治疗策略备受关注。2025年美国甲状腺学会（American Thyroid Association，ATA）发布了《2025版美国甲状腺学会成人分化型甲状腺癌管理指南》，在围手术期甲状旁腺功能保护和TSH抑制治疗方面有重要更新。2025版ATA指南推荐术中应用新方法识别并保护甲状旁腺，甲状腺全切术后采用基于甲状旁腺激素（parathyroid hormone，PTH）指导的钙剂和维生素D补充方案。TSH抑制治疗方面，2025版ATA指南取消初治期具体TSH目标值推荐，强调应根据患者初始复发风险和治疗反应动态调整TSH目标，实现个体化管理，避免过度治疗。

Abstract

In recent years

the incidence of differentiated thyroid cancer (DTC) continues to rise

with increasing attention to perioperative management and postoperative thyroid-stimulating hormone (TSH) suppression therapy strategies. The American Thyroid Association (ATA) released the “2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer” in 2025

which include significant updates on perioperative parathyroid function protection and TSH suppression therapy. In terms of perioperative management

the 2025 ATA guidelines recommend intraoperative application of novel methods to identify and protect the parathyroid glands

and adoption of parathyroid hormone (PTH)-guided calcium and vitamin D supplementation protocols following total thyroidectomy. Regarding TSH suppression therapy

the 2025 ATA guidelines eliminate specific TSH target value recommendations for initial treatment

emphasizing that TSH targets should be dynamically adjusted based on patients’ initial recurrence risk and treatment response to achieve individualized management and avoid overtreatment.

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references

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DOI：10.19401/j.cnki.1007-3639.2025.09.004

摘要

Abstract

关键词

Keywords

references