Risk factors associated with early recurrence of adenocarcinoma of esophagogastric junction (typeⅠ, Ⅱ) after radical resection

黄永高; 王鹏程; 王　嵩

doi:10.3969/j.issn.1007-3969.2016.05.018

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Risk factors associated with early recurrence of adenocarcinoma of esophagogastric junction (typeⅠ, Ⅱ) after radical resection

更新时间：2025-12-31

- Risk factors associated with early recurrence of adenocarcinoma of esophagogastric junction (typeⅠ, Ⅱ) after radical resection
- China Oncology Vol. 26, Issue 5, Pages: 458-461(2016)
- 作者机构：
  
  江苏泰州市人民医院胸外科,江苏,泰州,225300
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2016.05.018
  CLC：
- Published Online：23 June 2016，
  
  Published：23 June 2016
- 稿件说明：
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黄永高,王鹏程,王　嵩,等. Ⅰ、Ⅱ型食管胃连接处腺癌根治性切除[J]. 中国癌症杂志, 2016, 26(5): 458-461.

黄永高, 王鹏程, 王　嵩. Risk factors associated with early recurrence of adenocarcinoma of esophagogastric junction (typeⅠ, Ⅱ) after radical resection[J]. China Oncology, 2016, 26(5): 458-461.
黄永高,王鹏程,王　嵩,等. Ⅰ、Ⅱ型食管胃连接处腺癌根治性切除[J]. 中国癌症杂志, 2016, 26(5): 458-461. DOI： 10.3969/j.issn.1007-3969.2016.05.018.

黄永高, 王鹏程, 王　嵩. Risk factors associated with early recurrence of adenocarcinoma of esophagogastric junction (typeⅠ, Ⅱ) after radical resection[J]. China Oncology, 2016, 26(5): 458-461. DOI： 10.3969/j.issn.1007-3969.2016.05.018.

摘要

背景与目的：食管胃连接处腺癌(adenocarcinoma of esophagogastric junction，AEG)术后早期复发和转移的发生率高，预后差，而目前关于AEG术后复发的相关因素的研究很少。该研究通过阐明影响Ⅰ、Ⅱ型AEG术后早期复发的重要临床病理因素，从而可以对具有危险因素的患者提供积极的治疗，可能对改善预后有帮助。方法：该研究回顾性分析从2008年12月—2012年12月期间在江苏泰州市人民医院胸外科行根治性切除(R0切除)的145例Ⅰ、Ⅱ型AEG患者的临床资料，分析早期复发的相关危险因素。结果：R0切除后肿瘤复发的平均时间是25.4个月，1年内复发率为38.6%。单因素分析表明，组织学分级(肿瘤分化程度)、阳性淋巴结的数目、TNM分期和脉管侵犯与早期复发相关(P＜0.05)。Logistic多因素回归分析显示，只有组织学分级和脉管侵犯是肿瘤早期复发的独立相关因素(P＜0.05)。结论：组织学分级和脉管侵犯是预测Ⅰ、Ⅱ型AEG R0切除后肿瘤早期复发的独立危险因素。

Abstract

Background and purpose: Adenocarcinoma of the esophagogastric junction (AEG) has a high incidence of early recurrence and metastasis after operation. The prognosis of AEG is poor. However

few studies have investigated the recurrence of AEG. The purpose of this study was to clarify the important clinical pathological factors affecting the early recurrence of Ⅰ

Ⅱ type of AEG after operation. Thus more active treatment for patients at high risk of recurrence may improve the prognosis. Methods: This study retrospectively reviewed the clinical data from 145 AEG patients who underwent R0 resection during the period from Dec. 2008 to Dec. 2012. Risk factors associated with the early recurrence were analyzed. Results: The mean time to tumor recurrence was 25.4 months after R0 resection

and the 1-year recurrence rate was 38.6%. Univariate analysis showed that the histological grade (degree of tumor differentiation)

number of positive lymph nodes

TNM stage and vascular invasion were significantly related with the early recurrence (P0.05). Logistic multivariate regression analysis showed that only histological grade and vascular invasion were independently related with early tumor recurrence (P0.05). Conclusion: Histological grade and vascular invasion are independent risk factors for predicting the early tumor recurrence after R0 resection for AEG.

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