Background and purpose: Brain tumor is a major fatal neurological disease after cerebral apoplexy. The current study aimed to analyze the incidence and mortality of brain tumors among residents in former Luwan District of Shanghai from Jan. 2004 to Dec. 2011. Methods: The data of brain tumors in permanent residents of former Luwan District were collected from the database of cancer registration and management system in Shanghai. The incidence and mortality of brain tumors were calculated. The rates were standardized by the demographic composition developed in the Fifth Nationwide Census in the year 2000. The temporal trend in the incidence and mortality of brain tumors was assessed. Results: A total of 292 cases of brain tumors were diagnosed from Jan. 2004 to Dec. 2011

accounting for 2.80% of the total patients with malignant diseases. A total of 148 cases died of brain tumors during this period. There were no significant differences in brain tumor incidence and mortality between males and females. There were some fluctuations in the incidence and mortality rates of brain tumors for both males and females from 2004 to 2011. Conclusion: The occurrence of brain tumors and death happened in almost all age categories among permanent residents in former Luwan District of Shanghai from 2004 to 2011. Studying the epidemiology and mechanisms of brain tumor occurrence and progression can aid in the development of effective prevention and treatment strategies

and improve prognosis.