High risk human papillomavirus (HPV) has been considered as the most pathogenic factor in cervical cancer patients. Since the HPV vaccine was launched on the market

the detection of HPV and its clinical significance have become hot topics. We analysed the difficulties in peripheral blood detection of HPV and clinical practice

and demonstrated the significance including the latest research progress on prognosis and treatment. It has been verified that the persistent detection of HPV in peripheral blood is in accordance with poor prognosis. On this basis

the targeted therapy and immunotherapy for HPV appear more important in treatment. Focusing on the problem we want to solve

this review presented the current state of blood detection. In the end

we gave our perspective on the precise examination means and clinical application.