Pancreatic cancer is a highly lethal disease in gastrointestinal malignant tumors. The prognosis of patients with pancreatic cancer is poor

due to the rapid progression

lack of early diagnosis

low surgical resection rate and inefficiency of chemotherapy. The incidence of pancreatic cancer has increased significantly in the recent years. As the understanding of tumor behavior deepens

the basic research navigates new routes for clinical treatment and enriches clinical methods. Pancreatic cancer treatment has been transitioned from “surgery first” to multidisciplinary collaborative treatment team (MDT) models. In this review

we summarized recent high quality studies on pancreatic cancer including epidemiological investigation

pathogenic factor

advances in basic research

and clinical treatment.