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基因突变特征与儿童及青少年分化型甲状腺癌远处转移相关性的meta分析
Meta-analysis of the association between gene alterations and distant metastasis of differentiated thyroid carcinoma in children and adolescents
- 中国癌症杂志 2022年32卷第5期 页码：388-396
- 作者机构：
上海交通大学医学院附属仁济医院头颈外科,上海 200001
- 作者简介：
[ "邓姝婷（ORCID: 0000-0002-2894-5570）,本科 E-mail: 517710910039@shsmu.edu.cn" ]
[ "王卓颖,主任医师,博士研究生导师,现任上海交通大学医学院附属仁济医院头颈外科主任。主要从事甲状腺、唾液腺、软组织及其他头颈部良恶性肿瘤的诊断和治疗的临床及研究工作。担任中国临床肿瘤学会甲状腺癌专家委员会副主任委员,中国抗癌协会头颈肿瘤专业委员会常委。曾获得中国抗癌协会科技奖二等奖、上海市抗癌协会科技奖三等奖、2020年黄浦区领军人才等。主持国家自然科学基金面上项目两项,承担上海市自然科学基金及上海市科技委员会引导项目等,引导上海交通大学医学院“青年科技创新工作室”,负责及参与多项国际及全国多中心临床研究,发表论文50余篇,其中多篇发表在SCI收录期刊上。主编或参与编写论著6部。主持建立了多中心的儿童及青少年甲状腺癌临床数据库,对Hippo通路介导Treg细胞分化发育在调控青少年甲状腺癌淋巴结转移中的作用机制开展了深入研究。目前,已在甲状腺领域权威期刊Thyroid上发表首篇国内儿童及青少年分化型甲状腺癌临床数据及测序分析报道。此外,团队还领导并顺利开展“选择理想的甲状腺乳头状微小癌患者密切随访研究”“BRAF、TERT和RET/PTC基因检测辅助甲状腺结节良恶性诊断的前瞻性及双盲非干预性临床试验”“甲磺酸阿帕替尼片新辅助治疗局部晚期分化型甲状腺癌患者的有效性和安全性研究”等数项国内多中心前瞻性临床研究,建立了甲状腺结节穿刺诊断的多基因联合检测体系,协助甲状腺癌的精准诊断,也为晚期甲状腺癌患者提供了新的药物治疗方案,延长了生存时间,提高了生活质量。" ]
- 基金信息：国家自然科学基金(81972496);国家自然科学基金(81772852);上海市自然科学基金(16ZR1406600);2020年度黄浦区领军人才计划;共青团上海交通大学医学院委员会“甲状腺肿瘤防治”青年科技创新工作室
DOI：10.19401/j.cnki.1007-3639.2022.05.003
中图分类号： R736.1收稿：2022-03-25，
修回：2022-05-01，
纸质出版：2022-05-30
- 稿件说明：
移动端阅览
邓姝婷, 冯源, 钱凯, 等. 基因突变特征与儿童及青少年分化型甲状腺癌远处转移相关性的meta分析[J]. 中国癌症杂志, 2022,32(5):388-396.
Shuting DENG, Yuan FENG, Kai QIAN, et al. Meta-analysis of the association between gene alterations and distant metastasis of differentiated thyroid carcinoma in children and adolescents[J]. China Oncology, 2022, 32(5): 388-396.
邓姝婷, 冯源, 钱凯, 等. 基因突变特征与儿童及青少年分化型甲状腺癌远处转移相关性的meta分析[J]. 中国癌症杂志, 2022,32(5):388-396. DOI： 10.19401/j.cnki.1007-3639.2022.05.003.
Shuting DENG, Yuan FENG, Kai QIAN, et al. Meta-analysis of the association between gene alterations and distant metastasis of differentiated thyroid carcinoma in children and adolescents[J]. China Oncology, 2022, 32(5): 388-396. DOI： 10.19401/j.cnki.1007-3639.2022.05.003.
摘要
背景与目的：
甲状腺癌是世界范围内增长率较高的恶性肿瘤之一
在儿童及青少年中甲状腺癌的发病率也在逐年增加。本研究旨在对基因突变特征与儿童及青少年分化型甲状腺癌（differentiated thyroid carcinoma
DTC）远处转移的相关性进行meta分析。
方法：
数据库搜索探究基因突变特征与儿童及青少年DTC远处转移相关性的研究
运用STATA 14.0软件分析与远处转移相关的基因突变特征。
结果：
纳入20项研究
共涉及1 273例患者
分析结果显示
BRAF
V600E突变阴性、
RET
基因融合阳性是儿童及青少年DTC远处转移的危险因素
而
NTRK
基因融合与远处转移未见明显相关性。
结论：
本研究发现了与儿童及青少年DTC远处转移相关的几个基因突变特征
有利于患者预后的评估及治疗方案的制定。
Abstract
Background and purpose:
Thyroid cancer is one of the fastest increasing malignan
cies worldwide
and its incidence in children and adolescents has also been increasing over the years. Meta-analysis were performed to investigate the correlation between gene alteration patterns and distant metastasis of differentiated thyroid carcinoma (DTC) in children and adolescents.
Methods:
Databases were used to search studies on the association between gene alteration patterns and distant metastasis of DTC in children and adolescents
and STATA 14.0 software was used to analyze the gene alterations related to distant metastasis.
Results:
Twenty studies involving 1 273 patients were included
and the analysis showed that negative BRAF V600E mutation and positive RET gene fusion were risk factors for distant metastasis in DTC in children and adolescents
while NTRK gene fusion was not significantly associated with distant metastasis.
Conclusion:
Our research identified several genetic alterations associated with distant metastasis in DTC in children and adolescents
which could be guidance for prognosis assessment and treatment planning.
关键词
Keywords
references
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