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同济大学附属上海市肺科医院肿瘤科,上海 200433
[ "苏春霞(ORCID: 0000-0003-1632-9487),博士,主任医师,同济大学附属上海市肺科医院肿瘤科行政副主任、内科教研室副主任。E-mail: susu_mail@126.com。苏春霞,主任医师,同济大学教授、博士生导师,现任同济大学附属上海市肺科医院肿瘤科行政副主任、内科教研室副主任。在多个国际国内专业学会任职,包括2022年世界肺癌大会秘书、中国临床肿瘤学会(CSCO)患者教育专家委员会副主任委员、中华医学会肿瘤学分会青年委员、CSCO转化医学专家委员会副秘书长、CSCO免疫治疗专家委员会常务委员、上海抗癌协会青年理事会副理事长等。主持国家自然科学基金3项、申康新兴前沿技术课题等;作为执笔人撰写《CSCO免疫检查点抑制剂临床应用指南》、《CSCO免疫检查点抑制剂相关的毒性管理指南》及《上海市抗癌协会肺癌筛查指南》。以第一作者或通信作者在The Lancet Respiratory Medicine、Journal of Thoracic Oncology、NPJ Precis Oncol等SCI收录的学术期刊发表论文30余篇;主编及主译专著6部。获国家科技进步二等奖、上海科学技术进步一等奖、上海市科学技术普及个人二等奖、上海市科普教育创新奖个人二等奖等。" ]
周彩存(ORCID:0000-0002-7095-0381),博士,主任医师,同济大学附属上海市肺科医院肿瘤科主任、同济大学肿瘤学系主任。E-mail: caicunzhoudr@163.com
收稿:2022-05-27,
修回:2022-06-10,
纸质出版:2022-06-30
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苏春霞, 周彩存. 晚期非小细胞肺癌免疫治疗现状及未来方向[J]. 中国癌症杂志, 2022,32(6):478-486.
Chunxia SU, Caicun ZHOU. Current status and future directions of immunotherapy for advanced non-small cell lung cancer[J]. China Oncology, 2022, 32(6): 478-486.
苏春霞, 周彩存. 晚期非小细胞肺癌免疫治疗现状及未来方向[J]. 中国癌症杂志, 2022,32(6):478-486. DOI: 10.19401/j.cnki.1007-3639.2022.06.002.
Chunxia SU, Caicun ZHOU. Current status and future directions of immunotherapy for advanced non-small cell lung cancer[J]. China Oncology, 2022, 32(6): 478-486. DOI: 10.19401/j.cnki.1007-3639.2022.06.002.
肺癌仍然是中国发病率和死亡率最高的恶性肿瘤
其中非小细胞肺癌(non-small cell lung cancer
NSCLC)约占80%以上。以靶向程序性死亡[蛋白]-1(programmed death protein-1
PD-1)或程序性死亡[蛋白]配体-1(programmed death ligand-1
PD-L1)的免疫检查点抑制剂(immune checkpoint inhibitor
ICI)为基础的治疗已成为了晚期肺癌的标准治疗手段之一。本综述将对晚期NSCLC免疫治疗的现状予以梳理
探讨现阶段面临的问题与挑战
并思考与展望未来发展方向。
Lung cancer remains the malignant tumor with the highest morbidity and mortality in China
among which non-small cell lung cancer (NSCLC) accounts for more than 80%. Immune checkpoint inhibitors (ICIs)-based therapy targeting programmed death protein-1 (PD-1) or its ligand programmed death ligand-1 (PD-L1) has become one of the standard treatments for advanced NSCLC. This review
with the focus on advanced NSCLC
summarized the development of immunotherapy
discussed current problems
and challenges and proposed future directions.
ZHENG R S , ZHANG S W , ZENG H M , et al . Cancer incidence and mortality in China, 2016 [J ] . J Natl Cancer Cent , 2022 , 2 ( 1 ): 1 - 9 .
MOLINA J R , YANG P , CASSIVI S D , et al . Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship [J ] . Mayo Clin Proc , 2008 , 83 ( 5 ): 584 - 594 . DOI: 10.1016/S0025-6196(11)60735-0 http://doi.org/10.1016/S0025-6196(11)60735-0 https://linkinghub.elsevier.com/retrieve/pii/S0025619611607350 https://linkinghub.elsevier.com/retrieve/pii/S0025619611607350
YANG C Y , YANG J C H , YANG P C . Precision management of advanced non-small cell lung cancer [J ] . Annu Rev Med , 2020 , 71 : 117 - 136 . DOI: 10.1146/annurev-med-051718-013524 http://doi.org/10.1146/annurev-med-051718-013524 https://www.annualreviews.org/doi/10.1146/annurev-med-051718-013524 https://www.annualreviews.org/doi/10.1146/annurev-med-051718-013524
RECK M , RODRÍGUEZ-ABREU D , ROBINSON A G , et al . Pembrolizumab versus chemotherapy for PD-L1-positive non-small cell lung cancer [J ] . N Engl J Med , 2016 , 375 ( 19 ): 1823 - 1833 . DOI: 10.1056/NEJMoa1606774 http://doi.org/10.1056/NEJMoa1606774 http://www.nejm.org/doi/10.1056/NEJMoa1606774 http://www.nejm.org/doi/10.1056/NEJMoa1606774
BRAHMER J R , RODRIGUEZ-ABREU D , ROBINSON A G , et al. LBA51 KEYNOTE-024 5-year OS update: first-line (1L) pembrolizumab (pembro) vs platinum-based chemotherapy (chemo) in patients (pts) with metastatic NSCLC and PD-L1 tumour proportion score (TPS) & #x02265;50% [J ] . Ann Oncol , 2020 , 31 : S1181-S1182.
HERBST R S , GIACCONE G , DE MARINIS F , et al . Atezolizumab for first-line treatment of PD-L1-selected patients with NSCLC [J ] . N Engl J Med , 2020 , 383 ( 14 ): 1328 - 1339 . DOI: 10.1056/NEJMoa1917346 http://doi.org/10.1056/NEJMoa1917346 http://www.nejm.org/doi/10.1056/NEJMoa1917346 http://www.nejm.org/doi/10.1056/NEJMoa1917346
JASSEM J , DE MARINIS F , GIACCONE G , et al . Updated overall survival analysis from IMpower110: atezolizumab versus platinum-based chemotherapy in treatment-naive programmed death-ligand 1-selected NSCLC [J ] . J Thorac Oncol , 2021 , 16 ( 11 ): 1872 - 1882 . DOI: 10.1016/j.jtho.2021.06.019 http://doi.org/10.1016/j.jtho.2021.06.019 https://linkinghub.elsevier.com/retrieve/pii/S1556086421022863 https://linkinghub.elsevier.com/retrieve/pii/S1556086421022863
SEZER A , KILICKAP S , GÜMÜŞ M , et al . Cemiplimab monotherapy for first-line treatment of advanced non-small cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlled trial [J ] . Lancet , 2021 , 397 ( 10274 ): 592 - 604 . DOI: 10.1016/S0140-6736(21)00228-2 http://doi.org/10.1016/S0140-6736(21)00228-2 https://linkinghub.elsevier.com/retrieve/pii/S0140673621002282 https://linkinghub.elsevier.com/retrieve/pii/S0140673621002282
RECK M , RODRÍGUEZ-ABREU D , ROBINSON A G , et al . Five-year outcomes with pembrolizumab versus chemotherapy for metastatic non-small cell lung cancer with PD-L1 tumor proportion score ≥ 50 [J ] . J Clin Oncol , 2021 , 39 ( 21 ): 2339 - 2349 . DOI: 10.1200/JCO.21.00174 http://doi.org/10.1200/JCO.21.00174 https://ascopubs.org/doi/10.1200/JCO.21.00174 https://ascopubs.org/doi/10.1200/JCO.21.00174
HWANG D M , ALBAQER T , SANTIAGO R C , et al . Prevalence and heterogeneity of PD-L1 expression by 22C3 assay in routine population-based and reflexive clinical testing in lung cancer [J ] . J Thorac Oncol , 2021 , 16 ( 9 ): 1490 - 1500 . DOI: 10.1016/j.jtho.2021.03.028 http://doi.org/10.1016/j.jtho.2021.03.028 https://linkinghub.elsevier.com/retrieve/pii/S1556086421021080 https://linkinghub.elsevier.com/retrieve/pii/S1556086421021080
GANDHI L , RODRÍGUEZ-ABREU D , GADGEEL S , et al . Pembrolizumab plus chemotherapy in metastatic non-small cell lung cancer [J ] . N Engl J Med , 2018 , 378 ( 22 ): 2078 - 2092 . DOI: 10.1056/NEJMoa1801005 http://doi.org/10.1056/NEJMoa1801005 http://www.nejm.org/doi/10.1056/NEJMoa1801005 http://www.nejm.org/doi/10.1056/NEJMoa1801005
GADGEEL S , GARASSINO M C , ESTEBAN E , et al . KEYNOTE-189: OS update and progression after the next line of therapy (PFS2) with pembrolizumab + chemotherapy for metastatic nonsquamous NSCLC [J ] . J Thorac Oncol , 2019 , 14 ( 11 ): S1153 .
PAZ-ARES L , LUFT A , VICENTE D , et al . Pembrolizumab plus chemotherapy for squamous non-small cell lung cancer [J ] . N Engl J Med , 2018 , 379 ( 21 ): 2040 - 2051 . DOI: 10.1056/NEJMoa1810865 http://doi.org/10.1056/NEJMoa1810865 http://www.nejm.org/doi/10.1056/NEJMoa1810865 http://www.nejm.org/doi/10.1056/NEJMoa1810865
PAZ-ARES L , VICENTE D , TAFRESHI A , et al . A randomized, placebo-controlled trial of pembrolizumab plus chemotherapy in patients with metastatic squamous NSCLC: Protocol-specified final analysis of KEYNOTE-407 [J ] . J Thorac Oncol , 2020 , 15 ( 10 ): 1657 - 1669 . DOI: 10.1016/j.jtho.2020.06.015 http://doi.org/10.1016/j.jtho.2020.06.015 https://linkinghub.elsevier.com/retrieve/pii/S1556086420305001 https://linkinghub.elsevier.com/retrieve/pii/S1556086420305001
ZHOU C C , CHEN G Y , HUANG Y C , et al . Camrelizumab plus carboplatin and pemetrexed versus chemotherapy alone in chemotherapy-naive patients with advanced non-squamous non-small cell lung cancer (CameL): a randomised, open-label, multicentre, phase 3 trial [J ] . Lancet Respir Med , 2021 , 9 ( 3 ): 305 - 314 . DOI: 10.1016/S2213-2600(20)30365-9 http://doi.org/10.1016/S2213-2600(20)30365-9 https://linkinghub.elsevier.com/retrieve/pii/S2213260020303659 https://linkinghub.elsevier.com/retrieve/pii/S2213260020303659
YANG Y P , WANG Z H , FANG J , et al . Efficacy and safety of sintilimab plus pemetrexed and platinum as first-line treatment for locally advanced or metastatic nonsquamous NSCLC: a randomized, double-blind, phase 3 study (oncology program by innovent anti-PD-1-11) [J ] . J Thorac Oncol , 2020 , 15 ( 10 ): 1636 - 1646 . DOI: 10.1016/j.jtho.2020.07.014 http://doi.org/10.1016/j.jtho.2020.07.014 https://linkinghub.elsevier.com/retrieve/pii/S1556086420305955 https://linkinghub.elsevier.com/retrieve/pii/S1556086420305955
YANG Y P , SUN J Y , WANG Z H , et al . Updated overall survival data and predictive biomarkers of sintilimab plus pemetrexed and platinum as first-line treatment for locally advanced or metastatic nonsquamous NSCLC in the phase 3 ORIENT-11 study [J ] . J Thorac Oncol , 2021 , 16 ( 12 ): 2109 - 2120 . DOI: 10.1016/j.jtho.2021.07.015 http://doi.org/10.1016/j.jtho.2021.07.015 https://linkinghub.elsevier.com/retrieve/pii/S1556086421023303 https://linkinghub.elsevier.com/retrieve/pii/S1556086421023303
LU S , WANG J , YU Y , et al . Tislelizumab plus chemotherapy as first-line treatment for locally advanced or metastatic nonsquamous NSCLC (RATIONALE 304): a randomized phase 3 trial [J ] . J Thorac Oncol , 2021 , 16 ( 9 ): 1512 - 1522 . DOI: 10.1016/j.jtho.2021.05.005 http://doi.org/10.1016/j.jtho.2021.05.005 https://linkinghub.elsevier.com/retrieve/pii/S1556086421021766 https://linkinghub.elsevier.com/retrieve/pii/S1556086421021766
ZHOU C , REN S , CHEN J , et al . Camrelizumab or placebo plus carboplatin and paclitaxel as first-line treatment for advanced squamous NSCLC (CameL-sq): a randomized, double-blind, multicenter, phase Ⅲ trial [J ] . J Thorac Oncol , 2021 , 16 ( 4 ): S748.
WANG J , LU S , HU C , et al . Updated analysis of tislelizumab plus chemotherapy vs chemotherapy alone as first-line treatment of advanced squamous non-small cell lung cancer (SQ NSCLC) [J ] . Ann Oncol , 2020 , 31 : S817.
ZHOU C C , WU L , FAN Y , et al . Sintilimab plus platinum and gemcitabine as first-line treatment for advanced or metastatic squamous NSCLC: results from a randomized, double-blind, phase 3 trial (ORIENT-12) [J ] . J Thorac Oncol , 2021 , 16 ( 9 ): 1501 - 1511 . DOI: 10.1016/j.jtho.2021.04.011 http://doi.org/10.1016/j.jtho.2021.04.011 https://linkinghub.elsevier.com/retrieve/pii/S1556086421021286 https://linkinghub.elsevier.com/retrieve/pii/S1556086421021286
ZHOU C C , WANG Z P , SUN Y P , et al . Sugemalimab versus placebo, in combination with platinum-based chemotherapy, as first-line treatment of metastatic non-small cell lung cancer (GEMSTONE-302): interim and final analyses of a double-blind, randomised, phase 3 clinical trial [J ] . Lancet Oncol , 2022 , 23 ( 2 ): 220 - 233 . DOI: 10.1016/S1470-2045(21)00650-1 http://doi.org/10.1016/S1470-2045(21)00650-1 https://linkinghub.elsevier.com/retrieve/pii/S1470204521006501 https://linkinghub.elsevier.com/retrieve/pii/S1470204521006501
WANG J , WANG Z , WU L , et al . CHOICE-01: a phase 3 study of toripalimab versus placebo in combination with first-line chemotherapy for advanced NSCLC [J ] . J Thorac Oncol , 2021 , 16 ( 10 ): S927-S928 .
RECK M , JOTTE R , CAPPUZZO F , et al . IMpower150: analysis of efficacy in patients (pts) with liver metastases (mets) [J ] . Pneumologie , 2020 , 74 : S39-S39
YANG J C H , LUFT A , DE LA MORA JIMÉNEZ E , et al . Pembrolizumab (Pembro) with or without lenvatinib (Lenva) in first-line metastatic NSCLC with PD-L1 TPS ≥1% (LEAP-007): a phase Ⅲ, randomized, double-blind study [J ] . Ann Oncol , 2021 , 32 : S1429-S1430.
NISHIO M , PELED N , ZER A , et al . Phase Ⅲ LEAP-006 safety Run-in (Part 1): 1L pembrolizumab (Pembro) + chemotherapy (Chemo) with lenvatinib (Len) for metastatic NSCLC [J ] . Ann Oncol , 2020 , 31 : S848-S849.
REN S X , HE J X , FANG Y , et al . Camrelizumab plus apatinib in treatment-naive patients with advanced nonsquamous NSCLC: a multicenter, open-label, single-arm, phase 2 trial [J ] . JTO Clin Res Rep , 2022 , 3 ( 5 ): 100312 .
HAN B H , CHEN J , XIE Q , et al . A multicenter, randomized, phase 3 trial of penpulimab in combination with anlotinib or chemotherapy as first-line treatment in advanced NSCLC [J ] . J Thorac Oncol Off Publ Int Assoc Study Lung Cancer , 2021 , 16 ( 3 ): S650.
CHU T Q , ZHONG R B , ZHONG H , et al . Phase 1b study of sintilimab plus anlotinib as first-line therapy in patients with advanced NSCLC [J ] . J Thorac Oncol , 2021 , 16 ( 4 ): 643 - 652 . DOI: 10.1016/j.jtho.2020.11.026 http://doi.org/10.1016/j.jtho.2020.11.026 https://linkinghub.elsevier.com/retrieve/pii/S1556086420311011 https://linkinghub.elsevier.com/retrieve/pii/S1556086420311011
ZHAO S , REN S X , JIANG T , et al . Low-dose apatinib optimizes tumor microenvironment and potentiates antitumor effect of PD-1/PD-L1 blockade in lung cancer [J ] . Cancer Immunol Res , 2019 , 7 ( 4 ): 630 - 643 . DOI: 10.1158/2326-6066.CIR-17-0640 http://doi.org/10.1158/2326-6066.CIR-17-0640 https://aacrjournals.org/cancerimmunolres/article/7/4/630/469459/Low-Dose-Apatinib-Optimizes-Tumor-Microenvironment https://aacrjournals.org/cancerimmunolres/article/7/4/630/469459/Low-Dose-Apatinib-Optimizes-Tumor-Microenvironment
HELLMANN M D , PAZ-ARES L , BERNABE CARO R , et al . Nivolumab plus ipilimumab in advanced non-small cell lung cancer [J ] . N Engl J Med , 2019 , 381 ( 21 ): 2020 - 2031 . DOI: 10.1056/NEJMoa1910231 http://doi.org/10.1056/NEJMoa1910231 http://www.nejm.org/doi/10.1056/NEJMoa1910231 http://www.nejm.org/doi/10.1056/NEJMoa1910231
PAZ-ARES L G , RAMALINGAM S S , CIULEANU T E , et al . First-line nivolumab plus ipilimumab in advanced NSCLC: 4-year outcomes from the randomized, open-label, phase 3 CheckMate 227 part 1 trial [J ] . J Thorac Oncol , 2022 , 17 ( 2 ): 289 - 308 . DOI: 10.1016/j.jtho.2021.09.010 http://doi.org/10.1016/j.jtho.2021.09.010 https://linkinghub.elsevier.com/retrieve/pii/S155608642103207X https://linkinghub.elsevier.com/retrieve/pii/S155608642103207X
PAZ-ARES L , CIULEANU T E , COBO M , et al . First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial [J ] . Lancet Oncol , 2021 , 22 ( 2 ): 198 - 211 . DOI: 10.1016/S1470-2045(20)30641-0 http://doi.org/10.1016/S1470-2045(20)30641-0 https://linkinghub.elsevier.com/retrieve/pii/S1470204520306410 https://linkinghub.elsevier.com/retrieve/pii/S1470204520306410
JOHN T , SAKAI H , IKEDA S , et al. First-line (1L) nivolumab (NIVO) + ipilimumab (IPI) + chemotherapy (chemo) in Asian patients (pts) with advanced non-small cell lung cancer (NSCLC) from CheckMate 9LA [J ] . Ann Oncol , 2020 , 31 : S847-S848.
JOHNSON M , CHO B C , LUFT A , et al . Durvalumab ± tremelimumab + chemotherapy as first-line treatment for mNSCLC: results from the phase 3 POSEIDON study [J ] . J Thorac Oncol , 2021 , 16 ( 10 ): S844.
ABREU D R , RECK M , ŞENDUR N , et al . Pembrolizumab plus ipilimumab or placebo in previously untreated metastatic NSCLC with PD-L1 tumor proportion score ≥50%: KEYNOTE-598 3-year follow-up [J ] . Ann Oncol , 2022 , 33 : S30-S31.
MARUHASHI T , SUGIURA D , OKAZAKI I M , et al . LAG-3: from molecular functions to clinical applications [J ] . J Immunother Cancer , 2020 , 8 ( 2 ): e001014.
HODI F S , TAWBI H A , LIPSON E J , et al . Relatlimab (RELA) + nivolumab (NIVO) vs NIVO in previously untreated metastatic or unresectable melanoma: additional efficacy in RELATIV ITY-047 [J ] . Ann Oncol , 2021 , 32 : S867-S868.
MORGENSZTERN D , CHAUDHRY A , IANNOTTI N , et al . RELATIVITY-104: First-line relatlimab (RELA) + nivolumab (NIVO) with chemotherapy vs NIVO with chemotherapy in stage & #x02163; or recurrent non-small cell lung cancer (NSCLC): a phase & #x02161;, randomized, double-blind study [J ] . Ann Oncol , 2021 , 32 : S1030.
CHAUVIN J M , ZAROUR H M . TIGIT in cancer immunotherapy [J ] . J Immunother Cancer , 2020 , 8 ( 2 ): e000957.
CHO B C , ABREU D R , HUSSEIN M , et al . Tiragolumab plus atezolizumab versus placebo plus atezolizumab as a first-line treatment for PD-L1-selected non-small cell lung cancer (CITYSCAPE): primary and follow-up analyses of a randomised, double-blind, phase 2 study [J ] . Lancet Oncol , 2022 , 23 ( 6 ): 781 - 792 . DOI: 10.1016/S1470-2045(22)00226-1 http://doi.org/10.1016/S1470-2045(22)00226-1 https://linkinghub.elsevier.com/retrieve/pii/S1470204522002261 https://linkinghub.elsevier.com/retrieve/pii/S1470204522002261
MARIN-ACEVEDO J A , KIMBROUGH E O , LOU Y Y . Next generation of immune checkpoint inhibitors and beyond [J ] . J Hematol Oncol , 2021 , 14 ( 1 ): 45 . DOI: 10.1186/s13045-021-01056-8 http://doi.org/10.1186/s13045-021-01056-8 https://doi.org/10.1186/s13045-021-01056-8 https://doi.org/10.1186/s13045-021-01056-8
PAZ-ARES L , KIM T M , VICENTE D , et al . Bintrafusp Alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in second-line treatment of patients with NSCLC: results from an expansion cohort of a phase 1 trial [J ] . J Thorac Oncol , 2020 , 15 ( 7 ): 1210 - 1222 . DOI: 10.1016/j.jtho.2020.03.003 http://doi.org/10.1016/j.jtho.2020.03.003 https://linkinghub.elsevier.com/retrieve/pii/S1556086420301957 https://linkinghub.elsevier.com/retrieve/pii/S1556086420301957
WU L , CHEN B , YAO W , et al . A phase Ⅰb/Ⅱ trial of AK104 (PD-1/CTLA-4 bispecific antibody) in combination with anlotinib in advanced NSCLC [J ] . Ann Oncol , 2021 , 32 : S1006.
HONG M H , CLUBB J D , CHEN Y Y . Engineering CAR-T cells for next-generation cancer therapy [J ] . Cancer Cell , 2020 , 38 ( 4 ): 473 - 488 . DOI: 10.1016/j.ccell.2020.07.005 http://doi.org/10.1016/j.ccell.2020.07.005 https://linkinghub.elsevier.com/retrieve/pii/S1535610820303664 https://linkinghub.elsevier.com/retrieve/pii/S1535610820303664
QU J J , MEI Q H , CHEN L J , et al . Chimeric antigen receptor (CAR)-T-cell therapy in non-small cell lung cancer (NSCLC): current status and future perspectives [J ] . Cancer Immunol Immunother , 2021 , 70 ( 3 ): 619 - 631 . DOI: 10.1007/s00262-020-02735-0 http://doi.org/10.1007/s00262-020-02735-0 https://doi.org/10.1007/s00262-020-02735-0 https://doi.org/10.1007/s00262-020-02735-0
YILMAZ A , CUI H W , CALIGIURI M A , et al . Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy [J ] . J Hematol Oncol , 2020 , 13 ( 1 ): 168 . DOI: 10.1186/s13045-020-00998-9 http://doi.org/10.1186/s13045-020-00998-9 https://doi.org/10.1186/s13045-020-00998-9 https://doi.org/10.1186/s13045-020-00998-9
GOULDING J , BLUM R , HANCOCK B , et al . Abstract 1591: FT536: preclinical development of a novel off-the-shelf CAR-MICA/B NK cell immunotherapy combined with radiation and antibody treatments as a first-of-kind pan-cancer targeting strategy [J ] . Cancer Res , 2021 , 81 ( 13_Supplement ): 1591 . DOI: 10.1158/1538-7445.AM2021-1591 http://doi.org/10.1158/1538-7445.AM2021-1591 https://aacrjournals.org/cancerres/article/81/13_Supplement/1591/667388/Abstract-1591-FT536-Preclinical-development-of-a https://aacrjournals.org/cancerres/article/81/13_Supplement/1591/667388/Abstract-1591-FT536-Preclinical-development-of-a
HEMMINKI O , DOS SANTOS J M , HEMMINKI A . Oncolytic viruses for cancer immunotherapy [J ] . J Hematol Oncol , 2020 , 13 ( 1 ): 84 . DOI: 10.1186/s13045-020-00922-1 http://doi.org/10.1186/s13045-020-00922-1 https://doi.org/10.1186/s13045-020-00922-1 https://doi.org/10.1186/s13045-020-00922-1
SAXENA M , VAN DER BURG S H , MELIEF C J M , et al . Therapeutic cancer vaccines [J ] . Nat Rev Cancer , 2021 , 21 ( 6 ): 360 - 378 . DOI: 10.1038/s41568-021-00346-0 http://doi.org/10.1038/s41568-021-00346-0 https://doi.org/10.1038/s41568-021-00346-0 https://doi.org/10.1038/s41568-021-00346-0
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