前哨淋巴结时代乳腺癌的精准区域处理：演进与展望

邱鹏飞; 王永胜

doi:10.19401/j.cnki.1007-3639.2022.08.002

您当前的位置：

首页 >

文章列表页 >

前哨淋巴结时代乳腺癌的精准区域处理：演进与展望

专家述评 | 更新时间：2025-12-31

- 前哨淋巴结时代乳腺癌的精准区域处理：演进与展望
- Precise regional management of breast cancer in the sentinel lymph node era: evolution and prospect
- 中国癌症杂志 2022年32卷第8期页码：680-687
- 作者机构：
  
  山东省肿瘤防治研究院（山东省肿瘤医院）,山东第一医科大学（山东省医学科学院）,山东济南 250117
- 作者简介：
  
  [ "邱鹏飞（ORCID: 0000-0001-6784-410X）,主任医师,山东省肿瘤医院乳腺外科副主任,E-mail: qiupengfei2002@126.com。" ]
  [ "王永胜,二级教授、博士研究生导师,山东省肿瘤医院乳腺病中心主任。现任中国抗癌协会乳腺癌专业委员会副主任委员,中国抗癌协会国际医疗交流分会副主任委员,中国临床肿瘤学会乳腺癌专家委员会常务委员,中国医师协会肿瘤分会乳腺癌学组副组长,中华医学会肿瘤学分会乳腺癌学组委员,国家卫健委乳腺癌诊疗规范专家组成员,全球乳腺癌大会国际指导专家委员会成员,山东省抗癌协会靶向治疗分会主任委员。于国内率先开展乳腺癌保留乳房手术、前哨淋巴结活检替代腋窝淋巴结清扫术、乳腺病变微创诊断等研究,作为组长单位和首席专家,牵头开展了中国临床早期乳腺癌前哨淋巴结活检替代腋窝清扫术的多中心研究、乳腺癌内乳区前哨淋巴结活检术的多中心前瞻性临床验证研究和新型示踪技术引导乳腺癌内乳前哨淋巴结活检的多中心前瞻性临床研究,研究成果已达到国际领先水平,并参与多项国际和国内乳腺癌Ⅲ期临床研究。以第一作者或通信作者发表论文100余篇,其中在SCI收录期刊上发表论文30余篇,出版专著（译著等）共4部,授权国家发明专利2项,获奖成果共5项,其中国家级1项、部（省）级4项,作为主要负责人承担国家级项目4项、部（省）级项目3项。" ]
- 基金信息：
  
  国家自然科学基金(82172873);山东省自然科学基金(ZR2021QH002);中国博士后科学基金(2021M691334)
- DOI：10.19401/j.cnki.1007-3639.2022.08.002
  中图分类号： R737.9
- 收稿：2022-06-10，
  
  修回：2022-07-15，
  
  纸质出版：2022-08-30
- 稿件说明：
移动端阅览
邱鹏飞, 王永胜. 前哨淋巴结时代乳腺癌的精准区域处理：演进与展望[J]. 中国癌症杂志, 2022,32(8):680-687.

Pengfei QIU, Yongsheng WANG. Precise regional management of breast cancer in the sentinel lymph node era: evolution and prospect[J]. China Oncology, 2022, 32(8): 680-687.
邱鹏飞, 王永胜. 前哨淋巴结时代乳腺癌的精准区域处理：演进与展望[J]. 中国癌症杂志, 2022,32(8):680-687. DOI： 10.19401/j.cnki.1007-3639.2022.08.002.

Pengfei QIU, Yongsheng WANG. Precise regional management of breast cancer in the sentinel lymph node era: evolution and prospect[J]. China Oncology, 2022, 32(8): 680-687. DOI： 10.19401/j.cnki.1007-3639.2022.08.002.

摘要

区域淋巴结状况是乳腺癌重要的预后指标之一

可以指导分期和辅助治疗策略的制定。近30年来乳腺癌前哨淋巴结活检术（sentinel lymph node biopsy

SLNB）研究发展迅速

循证医学Ⅰ类证据支持其为临床腋窝淋巴结阴性早期乳腺癌患者安全、有效的腋窝分期技术

前哨淋巴结阴性及低肿瘤负荷患者SLNB替代腋窝淋巴结清扫术后腋窝复发风险和并发症极低。乳腺癌局部区域控制新理念——应该综合考虑远处转移风险、全身治疗效果与不良反应以及局部区域治疗（手术/放疗）效果与不良反应——推动了SLNB适应人群不断扩展

新辅助治疗与SLNB、内乳SLNB将进一步促进区域淋巴结处理降阶梯

豁免腋窝手术临床研究值得期待。SLNB标志着乳腺癌区域淋巴结迈入微创化精准诊疗时代。本文就前哨淋巴结时代乳腺癌的精准区域处理的演进过程和最新进展进行总结

以期为广大临床工作者提供参考。

Abstract

Regional lymph node status is one of the important prognostic indicators of breast cancer

which can guide the staging and adjuvant treatment strategy. Sentinel lymph node biopsy (SLNB) for breast cancer has developed rapidly over the past three decades

evidence-based medicine class Ⅰ evidence supports that SLNB is a safe and effective axillary staging technique for patients with clinically negative axillary lymph node in early breast cancer. The risk of axillary recurrence and complications in breast cancer patients with negative/few-positive sentinel lymph node omitting axillary lymph node dissection is very low. Locoregional management of breast cancer should consider the metastatic risk of the primary tumor

the efficacy and side effects of systemic therapy

and the efficacy and side effects of locoregional therapy (surgery/radiotherapy). This view has promoted the continuous expansion of the SLNB population. SLNB with neoadjuvant therapy and internal mammary SLNB will further promote the de-escalation therapy

and the ongoing studies of omission of axillary surgery should be anticipated. The era of precision medicine for regional lymph node management of breast cancer has gradually arrived with the development of SLNB. This article evaluated the latest progress of precise regional processing of breast cancer in the sentinel lymph node era

in order to provide reference for clinical doctors.

关键词

Keywords

references

BRACKSTONE M , BALDASSARRE F G , PERERA F E , et al . Management of the axilla in early-stage breast cancer: Ontario Health (Cancer Care Ontario) and ASCO guideline [J ] . J Clin Oncol , 2021 , 39 ( 27 ): 3056 - 3082 . DOI: 10.1200/JCO.21.00934 http://doi.org/10.1200/JCO.21.00934 https://ascopubs.org/doi/10.1200/JCO.21.00934 https://ascopubs.org/doi/10.1200/JCO.21.00934

HINDIÉ E . Skipping the lymphoscintigraphy step during sentinel node procedures in breast cancer: what information are we missing? [J ] . J Clin Oncol , 2019 , 37 ( 29 ): 2704 - 2705 . DOI: 10.1200/JCO.19.01612 http://doi.org/10.1200/JCO.19.01612 https://ascopubs.org/doi/10.1200/JCO.19.01612 https://ascopubs.org/doi/10.1200/JCO.19.01612

CHAGPAR A , MARTIN R C 3rd , CHAO C L , et al . Validation of subareolar and periareolar injection techniques for breast sentinel lymph node biopsy [J ] . Arch Surg , 2004 , 139 ( 6 ): 614 - 618 discussion 618-620. DOI: 10.1001/archsurg.139.6.614 http://doi.org/10.1001/archsurg.139.6.614 http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/archsurg.139.6.614 http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/archsurg.139.6.614

CONG B B , QIU P F , LIU Y B , et al . Validation study for the hypothesis of internal mammary sentinel lymph node lymphatic drainage in breast cancer [J ] . Oncotarget , 2016 , 7 ( 27 ): 41996 - 42006 . DOI: 10.18632/oncotarget.9634 http://doi.org/10.18632/oncotarget.9634 https://www.oncotarget.com/lookup/doi/10.18632/oncotarget.9634 https://www.oncotarget.com/lookup/doi/10.18632/oncotarget.9634

CAO X S , YANG G R , CONG B B , et al . The lymphatic drainage pattern of internal mammary sentinel lymph node identified by small particle radiotracer ( 99m Tc-dextran 40) in breast [J ] . Cancer Res Treat , 2019 , 51 ( 2 ): 483 - 492 . DOI: 10.4143/crt.2018.062 http://doi.org/10.4143/crt.2018.062 http://e-crt.org/journal/view.php?doi=10.4143/crt.2018.062 http://e-crt.org/journal/view.php?doi=10.4143/crt.2018.062

POORTMANS P . Postmastectomy radiation in breast cancer with one to three involved lymph nodes: ending the debate [J ] . Lancet , 2014 , 383 ( 9935 ): 2104 - 2106 . DOI: 10.1016/S0140-6736(14)60192-6 http://doi.org/10.1016/S0140-6736(14)60192-6 https://linkinghub.elsevier.com/retrieve/pii/S0140673614601926 https://linkinghub.elsevier.com/retrieve/pii/S0140673614601926

KRAG D N , WEAVER D L , ALEX J C , et al . Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe [J ] . Surg Oncol , 1993 , 2 ( 6 ): 335 - 339 ; discussion 340. DOI: 10.1016/0960-7404(93)90064-6 http://doi.org/10.1016/0960-7404(93)90064-6 https://linkinghub.elsevier.com/retrieve/pii/0960740493900646 https://linkinghub.elsevier.com/retrieve/pii/0960740493900646

KRAG D N , ANDERSON S J , JULIAN T B , et al . Sentinel lymph node resection compared with conventional axillary lymph node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial [J ] . Lancet Oncol , 2010 , 11 ( 10 ): 927 - 933 . DOI: 10.1016/S1470-2045(10)70207-2 http://doi.org/10.1016/S1470-2045(10)70207-2 https://linkinghub.elsevier.com/retrieve/pii/S1470204510702072 https://linkinghub.elsevier.com/retrieve/pii/S1470204510702072

MANSEL R E , FALLOWFIELD L , KISSIN M , et al . Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC trial [J ] . J Natl Cancer Inst , 2006 , 98 ( 9 ): 599 - 609 . DOI: 10.1093/jnci/djj158 http://doi.org/10.1093/jnci/djj158 http://academic.oup.com/jnci/article/98/9/599/2522073/Randomized-Multicenter-Trial-of-Sentinel-Node http://academic.oup.com/jnci/article/98/9/599/2522073/Randomized-Multicenter-Trial-of-Sentinel-Node

VERONESI U , PAGANELLI G , VIALE G , et al . A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer [J ] . N Engl J Med , 2003 , 349 ( 6 ): 546 - 553 . DOI: 10.1056/NEJMoa012782 http://doi.org/10.1056/NEJMoa012782 http://www.nejm.org/doi/abs/10.1056/NEJMoa012782 http://www.nejm.org/doi/abs/10.1056/NEJMoa012782

LYMAN G H , GIULIANO A E , SOMERFIELD M R , et al . American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer [J ] . J Clin Oncol , 2005 , 23 ( 30 ): 7703 - 7720 . DOI: 10.1200/JCO.2005.08.001 http://doi.org/10.1200/JCO.2005.08.001 https://ascopubs.org/doi/10.1200/JCO.2005.08.001 https://ascopubs.org/doi/10.1200/JCO.2005.08.001

GALIMBERTI V , COLE B F , VIALE G , et al . Axillary dissection versus no axillary dissection in patients with breast cancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised, controlled phase 3 trial [J ] . Lancet Oncol , 2018 , 19 ( 10 ): 1385 - 1393 . DOI: 10.1016/S1470-2045(18)30380-2 http://doi.org/10.1016/S1470-2045(18)30380-2 https://linkinghub.elsevier.com/retrieve/pii/S1470204518303802 https://linkinghub.elsevier.com/retrieve/pii/S1470204518303802

GIULIANO A E , BALLMAN K V , MCCALL L , et al . Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis: the ACOSOG Z0011 (alliance) randomized clinical trial [J ] . JAMA , 2017 , 318 ( 10 ): 918 - 926 . DOI: 10.1001/jama.2017.11470 http://doi.org/10.1001/jama.2017.11470 http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2017.11470 http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2017.11470

DONKER M , VAN TIENHOVEN G , STRAVER M E , et al . Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial [J ] . Lancet Oncol , 2014 , 15 ( 12 ): 1303 - 1310 . DOI: 10.1016/S1470-2045(14)70460-7 http://doi.org/10.1016/S1470-2045(14)70460-7 https://linkinghub.elsevier.com/retrieve/pii/S1470204514704607 https://linkinghub.elsevier.com/retrieve/pii/S1470204514704607

CONG B B , YU J M , WANG Y S . Axillary management still needed for patients with sentinel node micrometastases [J ] . Cancer Manag Res , 2019 , 11 : 2097 - 2100 . DOI: 10.2147/CMAR.S192573 http://doi.org/10.2147/CMAR.S192573 https://www.dovepress.com/axillary-management-still-needed-for-patients-with-sentinel-node-micro-peer-reviewed-article-CMAR https://www.dovepress.com/axillary-management-still-needed-for-patients-with-sentinel-node-micro-peer-reviewed-article-CMAR

FISHER B , JEONG J H , ANDERSON S , et al . Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation [J ] . N Engl J Med , 2002 , 347 ( 8 ): 567 - 575 . DOI: 10.1056/NEJMoa020128 http://doi.org/10.1056/NEJMoa020128 http://www.nejm.org/doi/abs/10.1056/NEJMoa020128 http://www.nejm.org/doi/abs/10.1056/NEJMoa020128

LOUIS-SYLVESTRE C , CLOUGH K , ASSELAIN B , et al . Axillary treatment in conservative management of operable breast cancer: dissection or radiotherapy? Results of a randomized study with 15 years of follow-up [J ] . J Clin Oncol , 2004 , 22 ( 1 ): 97 - 101 . DOI: 10.1200/JCO.2004.12.108 http://doi.org/10.1200/JCO.2004.12.108 https://ascopubs.org/doi/10.1200/JCO.2004.12.108 https://ascopubs.org/doi/10.1200/JCO.2004.12.108

SHI Z Q , WANG X E , QIU P F , et al . Predictive factors of pathologically node-negative disease for HER2 positive and triple-negative breast cancer after neoadjuvant therapy [J ] . Gland Surg , 2021 , 10 ( 1 ): 166 - 174 . DOI: 10.21037/gs-20-573 http://doi.org/10.21037/gs-20-573 https://gs.amegroups.com/article/view/60711/html https://gs.amegroups.com/article/view/60711/html

BURSTEIN H J , CURIGLIANO G , THÜRLIMANN B , et al . Customizing local and systemic therapies for women with early breast cancer: the St. Gallen international consensus guidelines for treatment of early breast cancer 2021 [J ] . Ann Oncol , 2021 , 32 ( 10 ): 1216 - 1235 . DOI: 10.1016/j.annonc.2021.06.023 http://doi.org/10.1016/j.annonc.2021.06.023 https://linkinghub.elsevier.com/retrieve/pii/S0923753421021049 https://linkinghub.elsevier.com/retrieve/pii/S0923753421021049

中国抗癌协会乳腺癌专业委员会 . 中国抗癌协会乳腺癌诊治指南与规范(2021年版) [J ] . 中国癌症杂志 , 2021 , 31 ( 10 ): 954 - 1040 .

The Society of Breast Cancer China Anti-Cancer Association . Guidelines for breast cancer diagnosis and treatment by China Anti-Cancer Association (2021 edition) [J ] . China Oncol , 2021 , 31 ( 10 ): 954 - 1040 .

BOUGHEY J C , SUMAN V J , MITTENDORF E A , et al . Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial [J ] . JAMA , 2013 , 310 ( 14 ): 1455 - 1461 . DOI: 10.1001/jama.2013.278932 http://doi.org/10.1001/jama.2013.278932 http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2013.278932 http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2013.278932

KUEHN T , BAUERFEIND I , FEHM T , et al . Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study [J ] . Lancet Oncol , 2013 , 14 ( 7 ): 609 - 618 . DOI: 10.1016/S1470-2045(13)70166-9 http://doi.org/10.1016/S1470-2045(13)70166-9 https://linkinghub.elsevier.com/retrieve/pii/S1470204513701669 https://linkinghub.elsevier.com/retrieve/pii/S1470204513701669

SIMONS J M , VAN NIJNATTEN T J A , VAN DER POL C C , et al . Diagnostic accuracy of different surgical procedures for axillary staging after neoadjuvant systemic therapy in node-positive breast cancer: a systematic review and meta-analysis [J ] . Ann Surg , 2019 , 269 ( 3 ): 432 - 442 . DOI: 10.1097/SLA.0000000000003075 http://doi.org/10.1097/SLA.0000000000003075 https://journals.lww.com/00000658-201903000-00010 https://journals.lww.com/00000658-201903000-00010

BARRIO A V , MONTAGNA G , MAMTANI A , et al . Nodal recurrence in patients with node-positive breast cancer treated with sentinel node biopsy alone after neoadjuvant chemotherapy-a rare event [J ] . JAMA Oncol , 2021 , 7 ( 12 ): 1851 - 1855 . DOI: 10.1001/jamaoncol.2021.4394 http://doi.org/10.1001/jamaoncol.2021.4394 https://jamanetwork.com/journals/jamaoncology/fullarticle/2784609 https://jamanetwork.com/journals/jamaoncology/fullarticle/2784609

KAHLER-RIBEIRO-FONTANA S , PAGAN E , MAGNONI F , et al . Long-term standard sentinel node biopsy after neoadjuvant treatment in breast cancer: a single institution ten-year follow-up [J ] . Eur J Surg Oncol , 2021 , 47 ( 4 ): 804 - 812 . DOI: 10.1016/j.ejso.2020.10.014 http://doi.org/10.1016/j.ejso.2020.10.014 https://linkinghub.elsevier.com/retrieve/pii/S0748798320308465 https://linkinghub.elsevier.com/retrieve/pii/S0748798320308465

王永胜 . 乳腺癌前哨淋巴结活检的安全性 [J ] . 中国癌症杂志 , 2006 , 16 ( 9 ): 685 - 688 .

WANG Y S . Safety issues of sentinel lymph node biopsy in breast cancer [J ] . China Oncol , 2006 , 16 ( 9 ): 685 - 688 .

BARRON A U , HOSKIN T L , DAY C N , et al . Association of low nodal positivity rate among patients with ERBB2-positive or triple-negative breast cancer and breast pathologic complete response to neoadjuvant chemotherapy [J ] . JAMA Surg , 2018 , 153 ( 12 ): 1120 - 1126 . DOI: 10.1001/jamasurg.2018.2696 http://doi.org/10.1001/jamasurg.2018.2696 http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jamasurg.2018.2696 http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jamasurg.2018.2696

SHI Z Q , QIU P F , LIU Y B , et al . Neo-adjuvant chemotherapy and axillary de-escalation management for patients with clinically node-negative breast cancer [J ] . Breast J , 2019 , 25 ( 6 ): 1154 - 1159 . DOI: 10.1111/tbj.13422 http://doi.org/10.1111/tbj.13422 https://onlinelibrary.wiley.com/doi/10.1111/tbj.13422 https://onlinelibrary.wiley.com/doi/10.1111/tbj.13422

BI Z , CHEN J J , LIU P C , et al . Candidates of genomic tests in HR + /HER2 - breast cancer patients with 1-2 positive sentinel lymph node without axillary lymph node dissection: analysis from multicentric cohorts [J ] . Front Oncol , 2021 , 11 : 722325 . DOI: 10.3389/fonc.2021.722325 http://doi.org/10.3389/fonc.2021.722325 https://www.frontiersin.org/articles/10.3389/fonc.2021.722325/full https://www.frontiersin.org/articles/10.3389/fonc.2021.722325/full

QI X W , DU J Z , TANG P , et al . Clinical significance of internal mammary lymph node metastasis for breast cancer: analysis of 337 breast cancer patients [J ] . Surg Oncol , 2018 , 27 ( 2 ): 185 - 191 . DOI: 10.1016/j.suronc.2018.03.006 http://doi.org/10.1016/j.suronc.2018.03.006 https://linkinghub.elsevier.com/retrieve/pii/S0960740418300355 https://linkinghub.elsevier.com/retrieve/pii/S0960740418300355

POORTMANS P M , WELTENS C , FORTPIED C , et al . Internal mammary and medial supraclavicular lymph node chain irradiation in stage Ⅰ-Ⅲ breast cancer (EORTC 22922/10925): 15-year results of a randomised, phase 3 trial [J ] . Lancet Oncol , 2020 , 21 ( 12 ): 1602 - 1610 . DOI: 10.1016/S1470-2045(20)30472-1 http://doi.org/10.1016/S1470-2045(20)30472-1 https://linkinghub.elsevier.com/retrieve/pii/S1470204520304721 https://linkinghub.elsevier.com/retrieve/pii/S1470204520304721

HENNEQUIN C , BOSSARD N , SERVAGI-VERNAT S , et al . Ten-year survival results of a randomized trial of irradiation of internal mammary nodes after mastectomy [J ] . Int J Radiat Oncol Biol Phys , 2013 , 86 ( 5 ): 860 - 866 . DOI: 10.1016/j.ijrobp.2013.03.021 http://doi.org/10.1016/j.ijrobp.2013.03.021 https://linkinghub.elsevier.com/retrieve/pii/S0360301613003325 https://linkinghub.elsevier.com/retrieve/pii/S0360301613003325

WHELAN T J , OLIVOTTO I A , PARULEKAR W R , et al . Regional nodal irradiation in early-stage breast cancer [J ] . N Engl J Med , 2015 , 373 ( 4 ): 307 - 316 . DOI: 10.1056/NEJMoa1415340 http://doi.org/10.1056/NEJMoa1415340 http://www.nejm.org/doi/10.1056/NEJMoa1415340 http://www.nejm.org/doi/10.1056/NEJMoa1415340

THORSEN L B J , OVERGAARD J , MATTHIESSEN L W , et al . Internal mammary node irradiation in patients with node-positive early breast cancer: fifteen-year results from the Danish breast cancer group internal mammary node study [J ] . J Clin Oncol , 2022 : JCO2200044.

DUANE F K , MCGALE P , TEOH S , et al . International variation in criteria for internal mammary chain radiotherapy [J ] . Clin Oncol (R Coll Radiol) , 2019 , 31 ( 7 ): 453 - 461 . DOI: 10.1016/j.clon.2019.04.007 http://doi.org/10.1016/j.clon.2019.04.007 https://linkinghub.elsevier.com/retrieve/pii/S0936655519301578 https://linkinghub.elsevier.com/retrieve/pii/S0936655519301578

QIU P F , LIU J J , LIU Y B , et al . A modified technology could significantly improve the visualization rate of the internal mammary sentinel lymph nodes in breast cancer patients [J ] . Breast Cancer Res Treat , 2012 , 136 ( 1 ): 319 - 321 . DOI: 10.1007/s10549-012-2203-5 http://doi.org/10.1007/s10549-012-2203-5 http://link.springer.com/10.1007/s10549-012-2203-5 http://link.springer.com/10.1007/s10549-012-2203-5

QIU P F , CONG B B , ZHAO R R , et al . Internal mammary sentinel lymph node biopsy with modified injection technique: high visualization rate and accurate staging [J ] . Medicine (Baltimore) , 2015 , 94 ( 41 ): e1790.

QIU P F , ZHAO R R , WANG W , et al . Internal mammary sentinel lymph node biopsy in clinically axillary lymph node-positive breast cancer: diagnosis and implications for patient management [J ] . Ann Surg Oncol , 2020 , 27 ( 2 ): 375 - 383 . DOI: 10.1245/s10434-019-07705-0 http://doi.org/10.1245/s10434-019-07705-0 https://doi.org/10.1245/s10434-019-07705-0 https://doi.org/10.1245/s10434-019-07705-0

王永胜 , 赵荣荣 , 刘雁冰 , 等 . 精准医学时代乳腺癌内乳前哨淋巴结活检适应证的探讨 [J ] . 中华肿瘤杂志 , 2019 , 41 ( 4 ): 251 - 256 .

WANG Y S , ZHAO R R , LIU Y B , et al . Discussion on the indications of internal mammary sentinel lymph node biopsy in breast cancer in the era of precision medicine [J ] . Chin J Oncol , 2019 , 41 ( 4 ): 251 - 256 .

CONG B B , QIU P F , WANG Y S . Internal mammary sentinel lymph node biopsy: minimally invasive staging and tailored internal mammary radiotherapy [J ] . Ann Surg Oncol , 2014 , 21 ( 7 ): 2119 - 2121 . DOI: 10.1245/s10434-014-3650-5 http://doi.org/10.1245/s10434-014-3650-5 http://link.springer.com/10.1245/s10434-014-3650-5 http://link.springer.com/10.1245/s10434-014-3650-5

QIU P F , WANG X E , WANG Y S . Indications for individual internal mammary node irradiation [J ] . Lancet Oncol , 2021 , 22 ( 2 ): e40.

BI Z , CHEN P , LIU J J , et al . Internal mammary sentinel lymph node biopsy after neoadjuvant chemotherapy in breast cancer [J ] . J Breast Cancer , 2018 , 21 ( 4 ): 442 - 446 . DOI: 10.4048/jbc.2018.21.e49 http://doi.org/10.4048/jbc.2018.21.e49 https://ejbc.kr/DOIx.php?id=10.4048/jbc.2018.21.e49 https://ejbc.kr/DOIx.php?id=10.4048/jbc.2018.21.e49

浏览量

2883

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

乳腺癌新辅助治疗后腋窝淋巴结转移情况分析

示踪用盐酸米托蒽醌注射液与核素用于乳腺癌前哨淋巴结活检的疗效对比研究

乳腺癌内乳前哨淋巴结活检与患者预后的相关性研究

乳腺癌外科治疗领域新技术的进展和争议

乳腺癌前哨淋巴结阳性豁免腋窝清扫后区域淋巴结放疗的回顾性研究