胃肠胰神经内分泌肿瘤临床前模型的研究进展

崔灵珺; 田超; 程梓轩; 郑佳彬; 苏菲; 谭煌英

doi:10.19401/j.cnki.1007-3639.2022.09.004

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胃肠胰神经内分泌肿瘤临床前模型的研究进展

专家述评 | 更新时间：2025-12-31

- 胃肠胰神经内分泌肿瘤临床前模型的研究进展
- Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm
- 中国癌症杂志 2022年32卷第9期页码：779-785
- 作者机构：
  
  1. 北京中医药大学研究生院,北京 100029
  2. 中日友好医院中西医结合肿瘤内科,北京 100029
- 作者简介：
  
  [ "崔灵珺（ORCID: 0000-0003-3690-7117）,学士。" ]
  [ "谭煌英,中日友好医院中西医结合肿瘤内科主任医师、教授,北京中医药大学/北京协和医学院博士研究生导师,中国抗癌协会胰腺癌专业委员会神经内分泌肿瘤学组副组长,中国临床肿瘤学会神经内分泌肿瘤专家委员会委员,中国医疗保健国际交流促进会神经内分泌肿瘤分会常务委员,中国抗癌协会整合肿瘤学分会常务委员,中国研究型医院学会肿瘤学专业委员会委员,北京中西医结合学会肿瘤专业委员会委员,中日友好医院神经内分泌肿瘤诊疗中心负责人,《中国临床肿瘤学会神经内分泌肿瘤诊疗指南（2021年版）》专家组副组长,《中国抗癌协会神经内分泌肿瘤诊治指南（2022年版）》编撰小组副主编,欧洲神经内分泌肿瘤学会会员。专注于神经内分泌肿瘤的诊断及中西医治疗,主持国家自然科学基金面上项目2项,参加国家重点研发计划项目1项。以通信作者或第一作者发表文章60余篇。" ]
- 基金信息：
  
  国家重点研发计划(2019YFB1309704)
- DOI：10.19401/j.cnki.1007-3639.2022.09.004
  中图分类号： R735
- 收稿：2022-07-01，
  
  修回：2022-08-05，
  
  纸质出版：2022-09-30
- 稿件说明：
移动端阅览
崔灵珺, 田超, 程梓轩, 等. 胃肠胰神经内分泌肿瘤临床前模型的研究进展[J]. 中国癌症杂志, 2022,32(9):779-785.

Lingjun CUI, Chao TIAN, Zixuan CHENG, et al. Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm[J]. China Oncology, 2022, 32(9): 779-785.
崔灵珺, 田超, 程梓轩, 等. 胃肠胰神经内分泌肿瘤临床前模型的研究进展[J]. 中国癌症杂志, 2022,32(9):779-785. DOI： 10.19401/j.cnki.1007-3639.2022.09.004.

Lingjun CUI, Chao TIAN, Zixuan CHENG, et al. Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm[J]. China Oncology, 2022, 32(9): 779-785. DOI： 10.19401/j.cnki.1007-3639.2022.09.004.

摘要

胃肠胰神经内分泌肿瘤（gastroenteropancreatic neuroendocrine neoplasm

GEP-NEN）是一种近年来发病率逐年升高的罕见异质性肿瘤

根据其分化程度

可分为神经内分泌瘤（neuroendocrine tumor

NET）和神经内分泌癌（neuroendocrine carcinoma

NEC）。随着对其发病机制和治疗手段的探索逐渐加深

临床前模型的重要性日渐凸显。本文就目前已发表的细胞系、类器官模型、人源肿瘤异种移植物模型及基因工程小鼠模型等临床前模型进行综述

并探讨这些模型目前的实际应用情况及其优缺点

旨在为未来研究提供新的思路和方向。

Abstract

Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is a rare

heterogeneous tumor that can be divided into neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) due to its degree of differentiation. With the gradual deepening of the exploration of its pathogenesis and treatment methods

the importance of preclinical models has become increasingly prominent. Here we reviewed the published preclinical models such as cell lines

organoid models

patient-derived xenograft models and genetically engineered mouse models. We also discussed the current practical applications of these models and their strengths and weaknesses

to provide threads and directions for future research.

关键词

Keywords

references

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