肝动脉栓塞术治疗囊性神经内分泌肿瘤肝转移的疗效及安全性分析

禹航; 刘文生; 张宁; 刘海宽; 陈洛海; 姚望; 范文哲; 李家平; 陈洁; 王于

doi:10.19401/j.cnki.1007-3639.2022.09.006

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肝动脉栓塞术治疗囊性神经内分泌肿瘤肝转移的疗效及安全性分析

专题论著 | 更新时间：2025-12-31

- 肝动脉栓塞术治疗囊性神经内分泌肿瘤肝转移的疗效及安全性分析
- The efficacy and safety analysis of transarterial embolization in the treatment of cystic neuroendocrine neoplasm liver metastasis
- 中国癌症杂志 2022年32卷第9期页码：794-799
- 作者机构：
  
  1. 中山大学附属第一医院肿瘤介入科,广东广州 510000
  2. 复旦大学附属肿瘤医院胰腺外科,复旦大学上海医学院肿瘤学系,复旦大学胰腺肿瘤研究所,上海市胰腺肿瘤研究所,上海 200032
  3. 中山大学附属第一医院消化内科,广东广州 510080
  4. 复旦大学附属肿瘤医院神经内分泌肿瘤中心,头颈及神经内分泌肿瘤内科,复旦大学上海医学院肿瘤学系,上海 200032
- 作者简介：
  
  [ "禹航（ORCID: 0000-0002-4903-352X）,硕士在读。" ]
  [ "王于,医学博士,主任医师,硕士研究生导师,中山大学附属第一医院肿瘤介入科副主任。广东省抗癌协会肿瘤微创介入专业委员会青年委员会副主任委员,广东省抗癌协会胆道肿瘤专业委员会青年委员会副主任委员,中华医学会消化病学分会胃肠激素与神经内分泌肿瘤学组委员,中国医师协会胰腺病学专业委员会胰腺神经内分泌肿瘤专业委员会委员,中国抗癌协会胰腺癌专业委员会神经内分泌肿瘤学组委员,广东省临床医学学会肿瘤介入学专业委员会常务委员兼秘书。主持多项国家自然科学基金及省部级基金课题。在Oncogene、Neuroendocrinology、Cancer Medicine、Cardiovascular and Interventional Radiology、BMC Cancer等SCI收录期刊上发表论著数十篇。" ]
- 基金信息：
  
  国家自然科学基金“罕见肿瘤研究专项”项目(82141104)
- DOI：10.19401/j.cnki.1007-3639.2022.09.006
  中图分类号： R735.7
- 收稿：2022-08-01，
  
  修回：2022-09-07，
  
  纸质出版：2022-09-30
- 稿件说明：
移动端阅览
禹航, 刘文生, 张宁, 等. 肝动脉栓塞术治疗囊性神经内分泌肿瘤肝转移的疗效及安全性分析[J]. 中国癌症杂志, 2022,32(9):794-799.

Hang YU, Wensheng LIU, Ning ZHANG, et al. The efficacy and safety analysis of transarterial embolization in the treatment of cystic neuroendocrine neoplasm liver metastasis[J]. China Oncology, 2022, 32(9): 794-799.
禹航, 刘文生, 张宁, 等. 肝动脉栓塞术治疗囊性神经内分泌肿瘤肝转移的疗效及安全性分析[J]. 中国癌症杂志, 2022,32(9):794-799. DOI： 10.19401/j.cnki.1007-3639.2022.09.006.

Hang YU, Wensheng LIU, Ning ZHANG, et al. The efficacy and safety analysis of transarterial embolization in the treatment of cystic neuroendocrine neoplasm liver metastasis[J]. China Oncology, 2022, 32(9): 794-799. DOI： 10.19401/j.cnki.1007-3639.2022.09.006.

摘要

背景与目的：

神经内分泌肿瘤（neuroendocrine neoplasm

NEN）常发生肝转移

但囊性NEN肝转移（cystic NEN liver metastasis

cNENLM）十分罕见

肝动脉栓塞术（transarterial embolization

TAE）治疗cNENLM的效果尚未见报道。本研究旨在分析cNENLM经TAE治疗后的疗效及安全性。

方法：

2016年1月

#x02014;2022年7月在中山大学附属第一医院及复旦大学附属肿瘤医院经TAE治疗的440例NENLM患者中共有囊性肝转移患者10例

按照实体瘤疗效评价标准（Response Evaluation Criteria in Solid Tumors

RECIST）1.1来评价疗效

分别计算其术后客观缓解率（objective response rate

ORR）、疾病控制率（disease control rate

DCR）及无进展生存期（progression-free survival

PFS）。术后不良反应分级采用常见不良事件评价标准（common terminology criteria for adverse events

CTCAE）v5.0。

结果：

按照RECIST 1.1来评价

ORR达到80.0%

DCR达到100.0%。10例患者中3例达到PFS

最长为25.0个月

其余患者尚未进展。不良反应主要为发热、肝区疼痛及肝功能一过性损伤等

对症处理后均可缓解

无严重术后并发症。

结论：

cNENLM十分罕见

TAE疗效佳

术后并发症可控。

Abstract

Background and Purpose:

Liver metastases are common in neuroendocrine neoplasm (NEN). C

ystic NEN liver metastases (cNENLM) are rare

and the efficacy of transarterial embolization (TAE) has not been reported. This study summarized and analyzed the efficacy and safety of TAE for cNENLM.

Methods:

From January 2016 to April 2022

10 patients with cNENLM were enrolled in this study among 440 patients under TAE treatment at The First Affiliated Hospital

Sun Yat-sen University and Fudan University Shanghai Cancer center. The efficacy was evaluated according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. Objective response rate (ORR)

disease control rate (DCR) and progression-free survival (PFS) were analyzed as well. The common terminology criteria for adverse events (CTCAE) v5.0 was applied to evaluate the adverse effects.

Results:

With 80.0% ORR and 100.0% DCR according to RECIST 1.1

3 cases achieved PFS. Among them

the longest one was 25.0 months. Disease progression was not observed in the remaining patients. The common complications were fever

hepatalgia and transient liver dysfunction

which could be alleviated by symptomatic treatment. No severe complication occurred.

Conclusion:

cNENLM are infrequent. TAE had significant curative effect on cNENLM

and complications were manageable.

关键词

Keywords

references

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