肾癌中调节性细胞死亡的新动向和未来展望

曹达龙 综述; 叶定伟 审校

doi:10.19401/j.cnki.1007-3639.2022.10.008

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肾癌中调节性细胞死亡的新动向和未来展望

综述 | 更新时间：2025-12-31

- 肾癌中调节性细胞死亡的新动向和未来展望
- New trends and future prospects of regulatory cell death in renal carcinoma
- 中国癌症杂志 2022年32卷第10期页码：1000-1006
- 作者机构：
  
  1. 复旦大学附属肿瘤医院泌尿外科，复旦大学上海医学院肿瘤学系，上海 200032
  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
- 作者简介：
  
  [ "曹达龙（ORCID: 0000-0001-8177-4347），副主任医师。" ]
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2022.10.008
  中图分类号： R737.11
- 收稿：2022-06-02，
  
  修回：2022-10-19，
  
  网络出版：2022-10-30，
- 稿件说明：
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曹达龙综述, 叶定伟审校. 肾癌中调节性细胞死亡的新动向和未来展望[J]. 中国癌症杂志, 2022,32(10):1000-1006.

Dalong CAO, Dingwei YE. New trends and future prospects of regulatory cell death in renal carcinoma[J]. China Oncology, 2022, 32(10): 1000-1006.
曹达龙综述, 叶定伟审校. 肾癌中调节性细胞死亡的新动向和未来展望[J]. 中国癌症杂志, 2022,32(10):1000-1006. DOI： 10.19401/j.cnki.1007-3639.2022.10.008.

Dalong CAO, Dingwei YE. New trends and future prospects of regulatory cell death in renal carcinoma[J]. China Oncology, 2022, 32(10): 1000-1006. DOI： 10.19401/j.cnki.1007-3639.2022.10.008.

摘要

肾癌是泌尿系统常见的恶性肿瘤之一。近年来，我国肾癌的发病率呈逐年上升的趋势，严重威胁着人们的健康。调节性细胞死亡是由一种细胞主动有序的死亡方式，普遍存在于生命活动过程中，在维系生命活动的平衡中发挥着至关重要的作用。近期

Science

杂志上报道了一种新的调节性细胞死亡方式即铜死亡，进一步强化了生命体中细胞死亡的重要性。随着对调节性细胞死亡认识的不断深入，越来越多的研究显示不同的调节性细胞死亡（如铁死亡、焦亡、自噬等）均与肾癌的发生、发展密切相关。如诱导细胞铁死亡将显著抑制肾癌的侵袭和转移、并与肾癌患者的更好预后密切相关；细胞焦亡不仅可以诱导肾癌细胞死亡还可以激活抗肾癌的免疫应答；自噬在肾癌中具有“双向”作用，增强自噬可抑制肾癌细胞生长，但也可能减弱联合用药治疗的效果；抑制细胞凋亡和坏死性凋亡可以显著促进肾癌细胞的增殖、侵袭等。本文将综述铁死亡、细胞焦亡、自噬、细胞凋亡和坏死性凋亡的分子机制和在肾癌发生、发展中作用的研究进展并进行展望，为探索肾癌的发病机制和潜在的治疗靶点提供新的视角。

Abstract

Renal cell carcinoma is one of the most common malignancies in genitourinary cancers. In China

the inc

idence of renal cell carcinoma has been increasing year by year. Regulated cell death is a cell-independent and orderly death controlled by genes

which is ubiquitous in organisms and plays a crucial role in maintaining the cell homeostasis. Recently

cuproptosis was reported in

Science

which further reinforced the importance of cell death in living organisms. With the increasing understanding of regulated cell death

more and more studies have shown that regulated cell death (such as ferroptosis

autophagy

pyroptosis) is closely related to the tumorigenesis and development of renal cell carcinoma. For example

induction of ferroptosis inhibits the invasion and metastasis of renal cell carcinoma and is closely related with better prognosis; pyroptosis not only induce renal cancer cell death and also activate the immune-response against renal cancer; autophagy plays a "bidirectional" role in renal cell carcinoma

which can inhibit the growth of renal cell carcinoma cells but may weaken the efficacy of combinational therapy; inhibition of apoptosis and necrotizing apoptosis can significantly promote the proliferation and invasion of renal cell carcinoma. This review has summarized the molecular mechanisms of ferroptosis

pyroptosis

autophagy

apoptosis and necrotizing apoptosis and the advances of different regulatory cell death in the tumorigenesis and development of renal cell carcinoma to provide a new perspective for exploring the mechanisms of tumorigenesis and potential targets of treatment.

关键词

Keywords

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