2022年乳腺癌基础与转化研究进展

王子彧; 肖毅; 江一舟; 邵志敏

doi:10.19401/j.cnki.1007-3639.2023.02.001

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2022年乳腺癌基础与转化研究进展

专家述评 | 更新时间：2025-12-31

- 2022年乳腺癌基础与转化研究进展
- Advances in fundamental and translational breast cancer research in 2022
- 中国癌症杂志 2023年33卷第2期页码：95-102
- 作者机构：
  
  复旦大学附属肿瘤医院乳腺外科/复旦大学乳腺癌研究所，复旦大学上海医学院肿瘤学系，上海 200032
- 作者简介：
  
  [ "王子彧（ORCID：0000-0002-3684-0816），复旦大学附属肿瘤医院博士研究生。" ]
  [ "邵志敏，主任医师，教授，首批教育部长江学者特聘教授，国家杰出青年科学基金项目获得者，复旦大学特聘教授，复旦大学肿瘤研究所所长，复旦大学乳腺癌研究所所长，复旦大学附属肿瘤医院大外科主任兼乳腺外科主任。现任中国抗癌协会靶向治疗专业委员会主任委员，上海市抗癌协会副理事长；曾任中国抗癌协会乳腺癌专业委员会主任委员，中华医学会肿瘤学分会副主任委员。担任第八届亚洲乳腺癌协会主席，St. Gallen乳腺癌大会专家团成员。主要从事乳腺癌的临床和基础研究，建立适合中国人群的早期筛查和诊疗流程，确立三阴性乳腺癌“复旦分型”和精准治疗策略，开展临床试验改善患者预后。已在Cancer Cell、Cell Metabolism、Cell Research、Journal of Clinical Oncology、JAMA Oncology、Journal of the National Cancer Institute等重要期刊上发表论著500余篇，被引用逾8 000次，主编专著10部。多次获得国家科技进步二等奖，教育部科技进步一、二等奖，卫健委科技进步一等奖，上海市科技进步一、二、三等奖，领衔团队入选教育部创新团队。先后主持国家自然科学基金重大项目、国家卫健委临床重点项目等国家级及省部级项目50余项。" ]
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2023.02.001
  中图分类号： R737.9
- 收稿：2023-01-08，
  
  修回：2023-01-24，
  
  纸质出版：2023-02-28
- 稿件说明：
移动端阅览
王子彧, 肖毅, 江一舟, 等. 2022年乳腺癌基础与转化研究进展[J]. 中国癌症杂志, 2023,33(2):95-102.

Ziyu WANG, Yi XIAO, Yizhou JIANG, et al. Advances in fundamental and translational breast cancer research in 2022[J]. China Oncology, 2023, 33(2): 95-102.
王子彧, 肖毅, 江一舟, 等. 2022年乳腺癌基础与转化研究进展[J]. 中国癌症杂志, 2023,33(2):95-102. DOI： 10.19401/j.cnki.1007-3639.2023.02.001.

Ziyu WANG, Yi XIAO, Yizhou JIANG, et al. Advances in fundamental and translational breast cancer research in 2022[J]. China Oncology, 2023, 33(2): 95-102. DOI： 10.19401/j.cnki.1007-3639.2023.02.001.

摘要

世界卫生组织（World Health Organization，WHO）国际癌症研究机构发布的数据显示，乳腺癌现已成为全球女性发病率最高的恶性肿瘤，严重威胁女性健康。2022年乳腺癌基础与转化研究领域进展颇丰，深化了对乳腺癌分子本质的认识，为乳腺癌精准治疗提供了新的思路。本文从肿瘤代谢、肿瘤微环境、微生物与肿瘤、肿瘤转移、肿瘤耐药与药物筛选、多组学研究、人工智能共7个方面对2022年乳腺癌基础与转化研究的年度进展进行总结，并对乳腺癌研究未来的发展方向进行展望，以期为乳腺癌研究的进一步深化提供参考。

Abstract

According to the data released by the International Cancer Research Institute of the World Health Organization (WHO)

breast cancer is the malignant tumor with the highest incidence rate in women

and seriously endangers women's health.Many impressive advances have been achieved in fundamental and translational research of breast cancer

which deepened the understanding of the molecular nature of breast cancer and provided new scientific strategies for the precision treatment of breast cancer. This paper summarized the annual advances in fundamental and translational breast cancer research in 2022 in seven sections: tumor metabolism

tumor microenvironment

microbes and tumors

tumor metastasis

tumor drug resistance and drug screening

multi-omics research and artificial intelligence. Furthermore

we proposed an outlook on the future directions of breast cancer research to provide a reference for future studies.

关键词

Keywords

references

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