抗EGFR单抗联合免疫检查点抑制剂治疗头颈部鳞状细胞癌专家共识（2025年版）

薛丽琼; 许婷婷; 郭晔; 胡超苏

doi:10.19401/j.cnki.1007-3639.2025.05.010

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抗EGFR单抗联合免疫检查点抑制剂治疗头颈部鳞状细胞癌专家共识（2025年版）

指南与共识 | 更新时间：2025-12-31

- 抗EGFR单抗联合免疫检查点抑制剂治疗头颈部鳞状细胞癌专家共识（2025年版）
- Expert consensus on the combination of anti-EGFR monoclonal antibodies and immune checkpoint inhibitors in the treatment of head and neck squamous cell carcinoma (2025 edition)
- 中国癌症杂志 2025年35卷第5期页码：510-522
- 作者机构：
  
  中国临床肿瘤学会头颈肿瘤专家委员会
- 作者简介：
  
  [ "薛丽琼（ORCID: 0000-0001-7037-4559），博士，副主任医师；" ]
  [ "许婷婷（ORCID: 0000-002-5920-808X），博士，副主任医师。" ]
  郭晔（ORCID: 0000-0002-1813-9815），博士，主任医师；
  胡超苏（ORCID: 0000-0001-6407-3311），博士，主任医师。
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2025.05.010
  中图分类号： R739.91
- 收稿：2025-04-16，
  
  修回：2025-05-16，
  
  纸质出版：2025-05-30
- 稿件说明：
移动端阅览
薛丽琼, 许婷婷, 郭晔, 等. 抗EGFR单抗联合免疫检查点抑制剂治疗头颈部鳞状细胞癌专家共识（2025年版）[J]. 中国癌症杂志, 2025,35(5):510-522.

Liqiong XUE, Tingting XU, Ye GUO, et al. Expert consensus on the combination of anti-EGFR monoclonal antibodies and immune checkpoint inhibitors in the treatment of head and neck squamous cell carcinoma (2025 edition)[J]. China Oncology, 2025, 35(5): 510-522.
薛丽琼, 许婷婷, 郭晔, 等. 抗EGFR单抗联合免疫检查点抑制剂治疗头颈部鳞状细胞癌专家共识（2025年版）[J]. 中国癌症杂志, 2025,35(5):510-522. DOI： 10.19401/j.cnki.1007-3639.2025.05.010.

Liqiong XUE, Tingting XU, Ye GUO, et al. Expert consensus on the combination of anti-EGFR monoclonal antibodies and immune checkpoint inhibitors in the treatment of head and neck squamous cell carcinoma (2025 edition)[J]. China Oncology, 2025, 35(5): 510-522. DOI： 10.19401/j.cnki.1007-3639.2025.05.010.

摘要

头颈部鳞状细胞癌（head and neck squamous cell carcinoma，HNSCC）是头颈部肿瘤最为常见的一种类型，其治疗效果及患者的预后并不理想，随着抗表皮生长因子受体（epidermal growth factor receptor，EGFR）单抗和免疫检查点抑制剂（immune checkpoint inhibitors，ICIs）的广泛应用，HNSCC患者的生存期虽有所延长但仍存在较大的改善空间。近年来多项研究提示，抗EGFR单抗联合ICIs治疗可带来良好的效果及安全性，已获得美国国立综合癌症网络（National Comprehensive Cancer Network，NCCN）和中国临床肿瘤学会（Chinese Society of Clinical Oncology，CSCO）等发布的权威性指南推荐。然而，抗EGFR单抗联合ICIs治疗方案的应用仍处于早期探索阶段，如何在临床中规范使用仍存在诸多待解答的问题，包括其协同作用机制、在不同类型患者中的治疗价值及安全性等。CSCO头颈肿瘤专家委员会组织专家基于循证医学证据及临床实践探索，经过多轮讨论，最终形成《抗EGFR单抗联合免疫检查点抑制剂治疗头颈部鳞状细胞癌专家共识（2025年版）》，对抗EGFR单抗与ICIs联合治疗的作用机制、分层治疗、在特殊人群中的应用及安全性等方面提出指导建议。本共识已在国际实践指南注册与透明化平台（Practice guideline REgistration for transPAREncy，PREPARE）上注册，注册号为PREPARE-2025CN666。期望本共识能够为临床医师提供更为明确和实用的指导，进一步推动该联合方案在临床实践中的合理应用，为HNSCC患者提供更多的治疗选择。

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer

and its treatment prognosis remains suboptimal. Although the survival of HNSCC patients has improved with the widespread use of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies and immune checkpoint inhibitors (ICIs)

there is still significant room for further improvement. Recent studies have suggested that the combination of anti-EGFR monoclonal antibodies and ICIs offers promising efficacy and safety

earning recommendations from authoritative guidelines such as the National Comprehensive Cancer Network (NCCN) and the Chinese Society of Clinical Oncology (CSCO). However

the application of this combination therapy is still in the early exploratory stage

numerous questions regarding the standardized clinical use of this combination therapy remain unanswered

including the mechanisms of synergy associated with the combination treatment

its therapeutic value in different patient populations

and safety considerations. Committee of Head and Neck Cancer

Chinese Society of Clinical Oncology organized an expert panel to develop “Expert consensus on the combination of anti-EGFR monoclonal antibodies and immune checkpoint inhibitors in the treatment of head and neck squamous cell carcinoma (2025 edition)”

based on evidence-based medicine and clinical practice exploration through multiple rounds of discussions. This consensus addressed the mechanisms of the combination of anti-EGFR monoclonal antibodies and ICIs

stratified treatment approaches

applications in special populations

and safety considerations. The consensus has been registered on Practice guideline REgistration for transPAREncy (PREPARE) with the registration number PREPARE-2025CN666. It is hoped that this consensus will provide clearer and more practical guidance for clinicians

further promoting the rational application of this combination therapy in clinical practice and offering more treatment options for HNSCC patients.

关键词

Keywords

references

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