Abstract:

The incidence rate of prostate cancer is showing an upward trend year by year, gradually becoming an important disease affecting the health of middle-aged and elderly men. The high-risk prostate cancer is a type of prostate cancer with at least one high-risk factor, which has a higher risk of metastasis and a poorer prognosis. Studies have indicated that 66% of patients who die from prostate cancer within 10 years are having high-risk prostate cancer. There is controversy regarding the value and significance of neoadjuvant and adjuvant therapy during the perioperative period for high-risk prostate cancer treatment. The consensus adopted the evidence-based medical method, extensively reviewed and organized relevant literature, conducted quality grade evaluations and evidence synthesis. After drafting the initial version, expert meetings and Delphi questionnaire surveys were conducted. After two rounds of surveys collecting opinions from 78 experts across 33 different cities and 71 hospitals, the data were summarized and refined. Relying on Society of Male Reproductive System Oncology, China Anti-Cancer Association for the “expert consensus on perioperative comprehensive treatment for high-risk prostate cancer (2023 edition)” was formulated. The aim was to explore and discuss neoadjuvant and adjuvant treatments for high-risk prostate cancer during the perioperative period, hoping to provide clinical doctors with guidance and standardized criteria for treating perioperative patients with high-risk prostate cancer.

Key words: High-risk prostate cancer, Perioperative period, Neoadjuvant therapy, Adjuvant therapy, Expert consensus