NRAS突变型晚期黑色素瘤的治疗进展

赵博伦, 朱冠男

Advances in the treatment of advanced melanoma with NRAS gene mutation

ZHAO Bolun, ZHU Guannan

图1 NRAS突变的信号转导示意图

Fig. 1 The schematic diagram of signal transduction of NRAS mutation Oncogenic signal transduction following NRAS mutation causes melanoma development mainly through MAPK signaling, PI3K-AKT signaling pathway and RAS-RAL signaling pathway. Black arrow: Conducted; Red arrow: Enhanced; Red area: Abnormal activation.