荧光原位杂交与尿脱落细胞学在尿路上皮癌诊断中的效能比较：一项单中心回顾性队列研究

王志婷, 任敏, 薛田, 王皓晨, 常恒, 柏乾明, 周晓燕, 朱晓丽

Comparison of fluorescence in situ hybridization (FISH) and urine cytology in diagnosing urothelial carcinoma: a single-center retrospective cohort study

WANG Zhiting, REN Min, XUE Tian, WANG Haochen, CHANG Heng, BAI Qianming, ZHOU Xiaoyan, ZHU Xiaoli

表3 FISH、脱落细胞学及联合检测在尿路上皮癌不同亚型中的诊断指标

Tab. 3 Diagnostic metrics of FISH, cytology, and combined testing for various subtypes of UC

Item	TP	FP	TN	FN	Accuracy/%	χ²	Sensitivity/%	χ²	Specificity/%	χ²	PPV/%	NPV/%
Invasive UC
FISH	68	20	127	11	86.28^a	6.48^#5.26^*	86.08^a	8.52^#2.25^*	86.39	0.15^#13.07^*	77.27	92.03
Cytology	53	23	124	26	78.32	6.48^#1.16^λ	67.09	8.52^#17.05^λ	84.35	0.15^#10.08^λ	69.74	82.67
Combined	72	35	112	7	81.42	5.26^*1.16^λ	91.14^b	2.25^*17.05^λ	76.19^b,c	13.07^*10.08^λ	67.29	94.12
Non-invasive UC
FISH	30	20	127	27	76.96	0.63^#4.05^*	52.63	0.31^#3.20^*	86.39	0.15^#13.07^*	60.00	82.47
Cytology	27	23	124	30	74.02	0.63^#0.45^λ	47.37	0.31^#6.13^λ	84.35	0.15^#10.08^λ	54.00	80.52
Combined	35	35	112	22	72.06	4.05^*0.45^λ	61.40^b	3.20^*6.13^λ	76.19^b,c	13.07^*10.08^λ	50.00	83.58
High-grade UC
FISH	93	20	127	19	84.94^a	8.07^#2.23^*	83.04	0.15^#5.14^*	86.39	0.15^#13.07^*	82.30	86.99
Cytology	74	23	124	38	76.45	8.07^#4.45^λ	66.07	0.15^#24.04^λ	84.35	0.15^#10.08^λ	76.29	76.54
Combined	100	35	112	12	81.85	2.23^*4.45^λ	89.29^b	5.14^*24.04^λ	76.19^b,c	13.07^*10.08^λ	74.07	90.32
Low-grade UC
FISH	5	20	127	19	77.19	0.03^#8.47^*	20.83	1.33^#0.50^*	86.39	0.15^#13.07^*	20.00	86.99
Cytology	6	23	124	18	76.02	0.03^#7.69^λ	25.00	1.33^#0.00^λ	84.35	0.15^#10.08^λ	20.69	87.32
Combined	7	35	112	17	69.59^b,c	8.47^*7.69^λ	29.17	0.50^*0.00^λ	76.19^b,c	13.07^*10.08^λ	16.67	86.82