EGFR T790M突变非小细胞肺癌患者的临床病理学、免疫微环境特征及对预后预测的意义

林艺聪, 王悦, 薛倩倩, 郑强, 金燕, 黄子凌, 李媛

Clinical pathological characteristics and immune microenvironment significance of EGFR T790M mutation in non-small cell lung cancer patients and its prognostic implications

LIN Yicong, WANG Yue, XUE Qianqian, ZHENG Qiang, JIN Yan, HUANG Ziling, LI Yuan

图4 EGFR TKI治疗后获得性T790M的免疫细胞空间分布特征

Fig. 4 Characterization of spatial distribution of immune cells in acquired T790M after treatment with EGFR TKI A-J: Comparison of the average distance between tumor cells and immune cells in 2 groups, EGFR with tumor suppressor gene mutations and EGFR mutations alone; K-T: Comparative assessment of immune cell infiltration density within a 200 μm radius at the peripheries of cancer nests between the EGFR with tumor suppressor gene mutation and EGFR mutation alone cohorts.