乳酸调控肿瘤恶性进程的研究进展

王智凌, 陈万金, 程胜桃

Research progress on the regulation of tumor malignancy by lactate

WANG Zhiling, CHEN Wanjin, CHENG Shengtao

图1 乳酸重塑肿瘤细胞代谢过程的示意图

Fig. 1 Schematic diagram of lactate reshaping the metabolic process of tumor cells A: High concentration of lactate regulates metabolism; B: Lactate regulates energy metabolism; C: lactate regulates amino acid metabolism; D: Lactate regulates lipid metabolism. TCA: Tricarboxylic acid cycle; Glut1: Glucose transporter 1; PDH: Pyruvate dehydrogenase; MPRL13: Mitochondrial ribosomal protein L13; CLDN1: Claudin-1; LDH1: Lactate dehydrogenase 1; PCK2: Phosphoenolpyruvate carboxykinase 2; ASCT2: alanine-serine-cysteine transporter 2; GLS1: Glutaminase 1.