乳酸调控肿瘤恶性进程的研究进展

王智凌, 陈万金, 程胜桃

Research progress on the regulation of tumor malignancy by lactate

WANG Zhiling, CHEN Wanjin, CHENG Shengtao

图2 乳酸重塑免疫抑制微环境的示意图

Fig. 2 Schematic diagram of lactate reshaping the immunosuppressive microenvironment A: Lactate inhibits the function of effector T cells; B: Lactate inhibits the activity of NK cells; C: Lactate promotes the polarization of macrophages. HDAC: Histone deacetylase; TCF7: Transcription factor 7; Gra B: Granzyme B.