MYC通过靶向CD47促进前列腺癌增殖和转移的机制研究

刘浩, 苏俊杰, 辛士永

Mechanism study of MYC promoting proliferation and metastasis in prostate cancer by targeting CD47

LIU Hao, SU Junjie, XIN Shiyong

图6 MYC与CD47之间的调控关系

Fig. 6 The regulatory relationship between MYC and CD47 A, B: After knocking down MYC, MYC and CD47 protein and mRNA levels in the cells changed; C: Immunohistochemical results; D: ChIP-PCR result. E: Validation of MYC expression in ChIP; F: Transwell results showed the effect of MYC and CD47 expression on the invasion ability of PCa cells; G: EdU experiment results showed the effect of MYC and CD47 expression levels on the proliferation of PCa cells; H, I: The results of colony formation and scratching experiments showed the effects of MYC and CD47 expression levels on the proliferation and migration of PCa cells.*: P<0.05; **: P<0.01; ***: P<0.001; NS: No significance.