MYC通过靶向CD47促进前列腺癌增殖和转移的机制研究

刘浩, 苏俊杰, 辛士永

Mechanism study of MYC promoting proliferation and metastasis in prostate cancer by targeting CD47

LIU Hao, SU Junjie, XIN Shiyong

图7 WFDC2+肿瘤样本中高评分组患者具有更高的免疫细胞浸润丰度

Fig. 7 WFDC2+ patients in the high-scoring group exhibit greater immune cell infiltration abundance A-C: Association of WFDC2+ tumor cell signature scores with CD8, MSI, TIDE, cell exclusion, and dysfunction; D: Differences in response to immunotherapy in high-rated and low-rated WFDC2+ tumor cells; E: Differences in stromal score, immune score and ESTIMATE score between high-rated and low-rated groups of WFDC2+ tumor cells; F: Validation sets demonstrated the difference in response to immunotherapy between high-rated and low-rated groups of WFDC2+ tumor cells; G: KEGG enrichment analysis was performed on the differential genes of WFDC2+ tumor cells in high and low rating groups; H: Correlation between the abundance of immune cell infiltration and WFDC2+ tumors; I: Differences of different biological processes in high-rated and low-rated WFDC2+ tumor cells.