逆转座元件异常活化在放疗晚反应中的研究进展与展望

温雅雯, 孙利 综述, 郑向鹏 审校

Derepression of retrotransposable elements in the development of radiation-induced late effects: advancements and perspective

WEN Yawen, SUN Li, ZHENG Xiangpeng

图1 逆转座元件活化导致类自身免疫性放疗晚期反应的机制简图

Fig. 1 The simplified conceptual diagram of radiation-induced reactivation of retrotransposable elements contributing to autoimmune inflammation-like late effects of radiotherapy Multiple downstream pathways may be involved including interferon and senescence-related signaling cascades as listed herein. RT: Radiotherapy; RVLP: Retrovirus-like particles; SASP: Senescence-associated secretory phenotype.